杨瑾

undefined

杨瑾

中共党员，医学博士，教授

太原市新建南路56号山西医科大学公共卫生学院

山西，中国，030001

Phone(o):(0351)3985922

E-mail：yang_jin@sxmu.edu.cn

教育经历

1993.9-1998.7，山西医科大学，本科，学士；

1998.9-2001.7，山西医科大学，研究生，硕士；

2004.9-2007.7，华中科技大学，研究生，博士。

工作经历

2001.7-至今，山西医科大学公共卫生学院劳动卫生学教研室

2008.8-2010.8，山西医科大学公共卫生与预防医学博士后科研流动站

访学经历

2015.12-2016.12，美国布朗大学公共卫生学院流行病学系访问学者

社会任职

中国诱变剂学会致癌专业委员会委员

中国诱变剂学会生物标志物专业委员会委员

中国毒理学会工业毒理专业委员会委员

中华预防医学会煤炭系统分会委员

国家医学考试中心命题组专家成员

《环境与职业医学》编委

研究方向：煤炭环境职业健康

代表性科研项目

1.Hippo-YAP介导的氨基酸代谢重编程在煤尘暴露致肺部干细胞样上皮细胞分化中的作用国家自然科学基金NSFC: 82574064)

2.SLC7A11介导的代谢重编程对苯并(a)芘致细胞恶性转化过程中基因甲基化的调控作用（国家自然科学基金NSFC: 82273606)

3.组蛋白泛素化关键因子Ring2在苯并(a)芘致细胞周期阻滞中的作用（国家自然科学基金NSFC：81273041）

4.泛素连接酶Ring2在苯并[a]芘致DNA损伤诱发的组蛋白泛素化中的作用（国家青年科学基金NSFC：30901180）

5.苯并(a)芘诱导支气管上皮细胞恶性转化过程中EMT基因甲基化模式改变的机制研究(山西省自然科学基金, 202103021224230)

6. H19/SAHH/DNMTs调控DNA甲基化在苯并(a)芘致细胞恶性转化中的作用(山西省留学人员科研资助, HGKY2019053)

7.长链非编码RNA H19在苯并(a)芘致DNA甲基化中的作用研究（山西省自然科学基金201701D121146）

8.山西省高等学校优秀青年学术带头人支持计划（晋教科【2010】4号）

代表性论著

1.Jiajun Wei, Xinyu Yao, Jingxuan Guo, Ying Guo, Yong Wang, Jinyu Wu, Hongyue Kong, Fengyu Qiu, Yu Zhang, Yizhou Liu, Jiawen Su, Jisheng Nie, Jin Yang*. The competitive mediating role of basal metabolic rate in the association between polycyclic aromatic hydrocarbon exposure and depression risk. Journal of Affective Disorders, 2025, 3, 13:S0165-0327(25)00405-7

2.Jiajun Wei; Yong Wang; Hongyue Kong; Jinyu Jin; Liuquan Jiang; Baolong Pan; Shugang Guo; Fan Yang; Gaisheng Liu; Fengyu Qiu; Jingxuan Guo; Yu Zhang; Jisheng Nie;Jin Yang*. Association between plasma CC16 levels and lung function changes in coke oven workers: A cohort study from 2014 to 2023, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2024, 284: 117002

3.Quan Feng, Jiajun Wei, Yong Wang, Jinyu Wu, Hongyue Kong, Shugang Guo, Gaisheng Liu, Jun Dong, Liuquan Jiang, Qiang Li, Jisheng Nie,Jin Yang*. Focusing on testosterone levels in male: A half-longitudinal study of polycyclic aromatic hydrocarbon exposure and diastolic blood pressure in coke oven workers. Environmental Pollution, 2023, 329:121614

4.Lu Liu, Jiajun Wei, Yong Wang, Quan Feng, Shugang Guo, Gaisheng Liu, Jun Dong, Liuquan Jiang, Qiang Li, Jisheng Nie,Jin Yang*. Effect of Club cell secretory proteins on the association of tobacco smoke and PAH co-exposure with lung function decline: A longitudinal observation of Chinese coke oven workers. International Journal of Hygiene and Environmental Health, 2023, 247:114058

5.Lu Liu, Quan Feng, Yong Wang, Xinyu Zhao, Shugang Guo, Lan Guo, Gaisheng Liu, Liuquan Jiang, Qiang Li, Baolong Pan, Jisheng Nie,Jin Yang*. Interaction of polycyclic aromatic hydrocarbon exposure and high-fasting plasma glucose on lung function decline in coke oven workers: a cross-lagged panel analysis. Environmental Toxicology and Pharmacology, 2022, 90: 103811

6.Xinyu Zhao, Aimin Yang, Ye Fu, Bin Zhang, Xuejing Li, Baolong Pan, Qiang Li, Jun Dong, Jisheng Nie,Jin Yang*. Reduction of mitochondrial DNA copy number in peripheral blood is related to polycyclic aromatic hydrocarbons exposure in coke oven workers: Bayesian kernel machine regression. Environmental Pollution, 2020, 260: 114026

7.Yanli Liu, Xuejing Li, Bin Zhang, Ye Fu, Aimin Yang, Hongjie Zhang, Huitao Zhang, Yingying Niu, Jisheng Nie, Jin Yang*. CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers. Environmental Health, 2019, 18(1):69-77

8. Yanli Liu, Hongjie Zhang, Huitao Zhang, Yingying Niu, Ye Fu, Jisheng Nie, Aimin Yang, Jinzhu Zhao,Jin Yang*, Mediation effect ofAhRexpression between polycyclic aromatic hydrocarbons exposure and oxidative DNA damage among Chinese occupational workers. Environmental Pollution, 2018, 243: 972-977

9.Jin Yang*, Yanli Liu, Huitao Zhang, Hongjie Zhang, Wubin Wang, Yanfeng Fan. Urinary 1-hydroxypyrene and smoking are determinants of LINE-1 and AhRR promoter methylation in coke oven workers. Mutation Research-Genetic Toxicology and Enviromental Mutagenesis, 2018, 826: 33-40

10.Jin Yang*, Huitao Zhang, Hongjie Zhang, Baolong Pan, Wubin Wang, Yanfeng Fan, Yanli Liu. S phase arrest in lymphocyte induced by urinary 1-hydroxypyrene and alcohol drinking in coke oven workers. Human and Experimental Toxicology, 2018, 37 (3): 229–239

专著

《环境、肿瘤和表观遗传学》,军事医学科学出版社, ISBN 978-7-80245-683-9

获奖

多环芳烃职业健康危害评估及防护对策研究,湖北省科技进步二等奖,2024