
韩浩
医学博士,副教授,硕士研究生导师
办公电话:0351-4135046
E-mail: hhxx13147799@126.com
教育经历:
2012.9-2015.7华中科技大学,营养与食品卫生学,博士
2010.9-2012.7华中科技大学,营养与食品卫生学,硕士
2005.9-2010.7山西医科大学预防医学本科,学士
工作经历
2015.7-至今山西医科大学公共卫生学院营养与食品卫生学教研室
学术任职
中国营养学会慢病分会委员、山西省营养学会理事
荣誉获奖
获2017年全国高校(医学类)微课教学比赛鼓励奖
教学情况
主要承担本科生《营养与食品卫生学学》、《预防医学》、《预防医学概论》、《临床营养学》课程以及研究生《临床营养》、《食物、营养与健康》、《文献导读与管理》等课程,主持校级教改课题1项
研究领域
膳食、营养与慢性病
代表性科研项目:
1.α-亚麻酸植物甾醇酯改善载脂蛋白E基因敲除小鼠高脂血症及AMPK介导的脂代谢信号调节机制研究。山西医科大学博士启动基金项目,03201518,2016. 01-2018.12
2.α-亚麻酸基于AMPK相关信号通路调控脂代谢和氧化应激改善动脉粥样硬化。山西省高等学校科技创新基金项目,2016154,2016. 04-2018. 04
3.α-亚麻酸植物甾醇酯基于AMPK相关信号通路调控脂代谢改善非酒精性脂肪肝。国家自然科学基金青年基金项目,81602856,2017. 01-2019. 12
4.以TBL为中心的多元化教学法在营养与食品卫生实践教学中应用与探索。山西医科大学教育教学改革研究项目,XJ2018122,2018. 05-2019. 12
5.亚麻油添加叶黄素对非酒精性脂肪肝病的改善作用及机制研究。山西省高等学校科技创新基金项目,2019L0420,2019. 07-2021. 07
6.α-亚麻酸调控内质网应激相关信号通路改善非酒精性脂肪肝的作用和机制研究。山西省自然科学基金面上青年基金,201901D211329,2019. 09-2022. 09
7.安琪纽特营养基金,酵母提取物改善酒精性肝病的作用及机制研究,AF2021003, 2021.08-2023.08, 30万元,主持,在研。
8.油料脂质化学与营养湖北省重点实验室开放基金项目。α-亚麻酸植物甾醇酯调控SIRT1抑制肝细胞焦亡改善非酒精性脂肪性肝炎的机制研究。5万元,主持,在研。
代表性论著:
Hao Han*, Tingli Xue , Jie Li , Yan Guo , Xiaoyu Li , Linqi Wang, Liyuan Pei, Mingming Zheng. Plant sterol ester of α-linolenic acid improved non-alcoholic fatty liver disease by attenuating endoplasmic reticulum stress-triggered apoptosis via activation of the AMPK. J Nutr Biochem. 2022; 107: 109072.
Hao Han*, Linqi Wang, Tingli Xue, Jie Li, Liyuan Pei, Mingming Zheng. Plant sterol ester of α-linolenic acid improves NAFLD through modulating gut microbiota and attenuating lipopolysaccharide-induced inflammation via regulating TLR4/NF-κB signaling pathway. Journal of Functional Foods. 2022;94: 1051371.
Han H*, Li X, Guo Y, Zheng M, Xue T, Wang L. Plant sterol ester of alpha-linolenic acid ameliorates high-fat diet-induced nonalcoholic fatty liver disease in mice: association with regulating mitochondrial dysfunction and oxidative stress via activating AMPK signaling. Food Funct. 2021;12(5): 2171-2188.
Han H*, Guo Y, Li X, Shi D, Xue T, Wang L, Li Y, Zheng M. Plant Sterol Ester of alpha-Linolenic Acid Attenuates Nonalcoholic Fatty Liver Disease by Rescuing the Adaption to Endoplasmic Reticulum Stress and Enhancing Mitochondrial Biogenesis, Oxid Med Cell Longev. 2019; 2019: 8294141.
5. Han H*, Qiu F, Zhao H, Tang H, Li X, Shi D. Dietary flaxseed oil improved western-type diet-induced atherosclerosis in apolipoprotein-E knockout mice. J Funct Foods. 2018; 40: 417-425.
6. Han H*, Qiu F, Zhao H, Tang H, Li X, Shi D. Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice. Oxid Med Cell Longev. 2017; 2017: 3256241.
7. Han H, Ma H, Rong S, Chen L, Shan Z, Xu J, Zhang Y, Liu L. Flaxseed oil containing flaxseed oil ester of plant sterols attenuates high-fat diet-induced hepatic steatosis in apolipoprotein-E knockout mice. J Funct Foods. 2015; 13: 169-182.
8. Han H*Yan P, Chen L, Luo C, Gao H, Deng Q, Zheng M, Shi Y, Liu L. Flaxseed Oil Containing alpha -Linolenic Acid Ester of Plant Sterol Improved Atherosclerosis in ApoE Deficient Mice. Oxid Med Cell Longev. 2015; 2015: 958217.
9.Han H, Cui W, Wang L, Xiong Y, Liu L, Sun X, Hao L. Lutein prevents high fat diet-induced atherosclerosis in ApoE-deficient mice by inhibiting NADPH oxidase and increasing PPAR expression. Lipids. 2015 Mar; 50(3): 261-73.