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雷立健

2016年08月31日 17:35  点击:[]

 

教育经历

 1990-1995年,山西医学院,预防医学系,大学本科

 1995-1998年,山西医科大学,公共卫生学院,硕士研究生

 2001-2005年,复旦大学,公共卫生学院,博士研究生

研究工作经历

 19987-20017月,山西医科大学,公共卫生学院劳动卫生教研室,讲师

 20057-20087月,复旦大学,公共卫生学院劳动卫生教研室,讲师

 20089-至今,山西医科大学,公共卫生学院流行病学教研室,副教授

 20138-20148月,美国纽约州立大学布法罗分校Department of Epidemiology and Environmental Medicine 进修学习一年。    

       

学术任职

现为中华预防医学会伤害预防与控制专科委员会第一届常委委员

国家医师资格考试公共卫生类别试题开发委员会委员

山西省专家学者协会医学分会理事

山西省科技厅专家

太原市卫生应急专家

《环境与职业医学》和《中国医药导报》杂志审稿人

广西省自然科学基金评审专家

广东省科技厅科技咨询专家。

       

科研情况

多年来一直从事职业流行病学和环境流行病学研究,关注重金属污染对人群的健康效应。近年在国内外相关期刊发表学术论文20余篇,参编教材3部,主持国家、省级科研项目及横向课题5项。

 

主持的科研项目

1.       miRNA的表达在职业镉暴露致肾功能损伤中的作用. No.812730402013/01-2016/12 国家自然科学基金项目

2.       镉致肾小管功能损伤中miRNA表达改变与氧化应激的关系。No.2015-055. 2015/11-2018/11.山西省出国留学人员科研资助项目

3.       线粒体DNA copy number的变异与煤矿工人高血压的关系. KY2015006. 2015/07-2017/06. 山西省煤矿公共卫生研究生教育创新中心        

4.       镉接触对糖尿病肾病的影响及其与遗传因素的交互作. No. 2012011039-72012.1-2014.12山西省科技厅山西省基础研究计划项目(自然)资助        

5.       血浆MTAb与镉致肾功能损伤时间-效应关系的研究. No. 20091011,山西省高等学校科技研究开发项目,2009.6-2011          

近年发表文章

1.       Lei L, Chang X, Rentschler G, Tian L, Zhu G, Chen X, Jin T, Broberg K. A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2-microglobulin.Toxicol Appl Pharmacol. 2012, 15; 265(3) :373-9.        

2.       Lei LJ, Chen L, Jin TY, Nordberg M, Chang XL. Estimation of Benchmark Dose for Pancreatic Damage in Cadmium-Exposed Smelters. Toxicological Sciences2007, 97(1): 189-195.

3.      Li-Jian, Lei, Tai-Yi Jin, Yuan-Fen Zhou. Insulin expression in rats exposed to cadmium. Biomedical and Environmental Sciences2007, 20: 295-301.

4.      Liang Chen, Lijian Lei, Taiyui Jin, Monica Norberg, Gunnar Norberg. Plasma Metallothionein Antibody, Urinary Cadmium, and Renal Dysfunction in a Chinese Type 2 Diabetic Population. DIABETES CARE. 2006, 29 (12): 2682-2687 (并列第一作者)

5.      史秀京,雷立健郭建勇国艳康辉. 镉致大鼠肾脏miRNA-21表达的生物信息学分析. 环境与职业医学.2016332:113-118(通讯作者)

6.      雷立健,史秀京,郭建勇,冯希云,张晋峰,王君. 太原市某医院2型糖尿病患者肾脏功能状况调查及影响因素分析.中国预防医学杂志.2016,32-36

7.      Lei X, Lei L, Zhang Z, Zhang Z, Cheng Y.Downregulated miR -29c correlates with increased BACE1 expression in sporadic Alzheimer's disease. Int J Clin Exp Pathol. 2015.8(2):1565-74.

8.      Lei X, Lei L, Zhang Z, Cheng Y.Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia‑reperfusion in rats: The role of the Nrf2/HO‑1 signaling pathway.Mol Med Rep. 2015.13(1):299-301.        

9.      Zhang CLiang YHLei LJHypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium[J].Toxicology and Applied Pharmacology2013271 ( 1) : 78-85

10.  Liang Y, Lei L, Nilsson J, Li H, Nordberg M, Bernard A, Nordberg GF, Bergdahl IA, Jin T. Renal Function after Reduction in Cadmium Exposure: An 8-Year Follow-up of Residents in Cadmium-Polluted Areas. Environ Health Perspect. 2012, 120(2):223-8.

11.  Chen X, Zhu G, Lei L, Jin T. The association between blood pressure and blood cadmium in a Chinese population living in cadmium polluted area. Environ ToxicolPharmacol. 2013, 36(2), 595-9

12.  Zhang C, Liang Y, Lei L, Zhu G, Chen X, Jin T, Wu Q. Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium. ToxicolApplPharmacol. 2013, 271(1)78-85

13.  Xiao Chen, Lijian Lei, LitingTian, Guoying Zhu, Taiyi Jin. Bone mineral density and polymorphisms in metallothionein 1A   and 2A in a Chinese population exposed to cadmium. Science of The Total Environment. 2012, 423(15),  12-17

14.  Nordberg G, Jin T, Wu X, Lu J, Chen L, Liang Y, Lei L, Hong F, Bergdahl IA, Nordberg M.Kidney dysfunction and cadmium exposure--factors influencing dose-response relationships.J Trace Elem Med Biol. 2012, 26(2-3), 197-200.

15.  Chen X, Zhu G, Jin T, Lei L, Liang Y. Bone mineral density is related with previous renal dysfunction caused by cadmium exposure. Environ Toxicol Pharmacol. 2011, 32(1):46-53.

16.  Zheng G, Tian L, Liang Y, Broberg K, Lei L, Guo W, Nilsson J, Bergdahl IA, Skerfving S, Jin T. δ-aminolevulinic acid dehydratase genotype predicts toxic effects of lead on workers’peripheral nervous system. Neurotoxicology, 2011, 32(4): 374-82.

17.  Liang Y, Li H, Xiang C, Lei L, Jin T, Nordberg M, Nordberg GF.Increased hepatic and decreased urinary metallothionein in rats after cessation of oral cadmium exposure.Basic ClinPharmacolToxicol. 2010 , 106(4), 348-55

18.   Liang Y, Li H, Xiang C, Lei L, Jin T, Nordberg M, Nordberg GF. Increased hepatic and decreased urinary metallothionein in rats after cessation of oral cadmium exposure.Basic Clin Pharmacol Toxicol. 2010106(4): 348-55.

19.  Chen X, Zhu G, Jin T, Akesson A, Bergdahl IA , Lei L, Weng S, Liang Y. Changes in bone mineral density 10 years after marked reduction of cadmium exposure in a Chinese population. Environ Res. 2009109 (7):874-9.

20.   Nordberg GF, Jin T, Wu X, Lu J, Chen L, Lei L, Hong F, Nordberg M.Prevalence of kidney dysfunction in humans - relationship to cadmium dose, metallothionein, immunological and metabolic factors.Biochimie. 2009; 91(10):1282-5.

21.  Chang X, Jin T, Chen L, Nordberg M, Lei L. Metallothionein I isoform mRNA expression in peripheral lymphocytes as a biomarker for occupational cadmium exposure. Exp Biol Med ( Maywood ). 2009; 234(6):666-72.

22.   Wu X, Liang Y, Jin T, Ye T, Kong Q, Wang Z, Lei L, Bergdahl IA, Nordberg GF. Renal effects evolution in a Chinese population after reduction of cadmium exposure in rice.Environ Res. 2008; 108(2):233-8.

23.  Sun Y, Sun D, Zhou Z, Zhu G, Lei L, Zhang H, Chang X, Jin T. Estimation of benchmark dose for bone damage and renal dysfunction in a Chinese male population occupationally exposed to lead.Ann Occup Hyg. 2008; 52(6):527-33.            

24.  Chen L, Jin T, Huang B, Chang X, Lei L, Nordberg GF, Nordberg M.Plasma metallothionein antibody and cadmium-induced renal dysfunction in an occupational population in China.Toxicol Sci. 2006; 91(1):104-12.

荣誉和成果

1. 山西医科大学公共卫生学院2016届本科毕业论文优秀指导教师        

2. 金属硫蛋白 1A 基因多态性与镉暴露所致尿β2微球蛋白的关系. 2015年获第十七届山西省优秀学术论文二等奖(排名第一)      

3. 金属硫蛋白,金属硫蛋白抗体与镉致健康损害:2007年荣获中华预防医学会科学技术奖二等奖和上海医学科技奖三等奖(金泰廙,陈亮,常秀丽,卢坚,雷立健,黄波,曾祥斌,陈珏,邵波,宁勇,逄兵)        

4. 糖尿病危险因素的流行病学研究:2007年荣获上海市宝山科技进步二等奖(黄红儿,金泰廙,杨群娣,雷立健,周袁芬,刘世友)

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