成晓龙
山西医科大学，基础医学院，教授
教育经历（从大学本科开始，按时间倒序排序；请列出攻读研究生学位阶段导师姓名）：
1.2001/9–2004/7， 山西医科大学， 生理学， 博士， 导师：赵荣瑞
2.1994/9–1997/7， 山西医科大学， 人体解剖与组织胚胎学， 硕士，
导师：王绍坤
3.1989/9–1994/7， 山西医学院， 临床医学， 学士 ;
科研与学术工作经历（按时间倒序排序；如为在站博士后研究人员或曾进入博士后流动站（或工作站）从事研究，请列出合作导师姓名）：
1.2010/1 -至今，山西医科大学，基础医学院，教授
2.2004/9-2010/1，山西医科大学，基础医学院，副教授
3.1999/7-2004/8，山西医科大学，基础医学院，讲师
4.1997/7-1999/6，山西医科大学，基础医学院，助教
曾使用其他证件信息（申请人应使用唯一身份证件申请项目，曾经使用其他身份证件作为申请人或主要参与者获得过项目资助的，应当在此列明）：主持或参加科研项目（课题）及人才计划项目情况（按时间倒序排序）：
1.国家自然科学基金面上项目,81672768,AJUBA基因在食管癌中的作用及机制研究, 2017/01-2020/12，73万，在研，主持；
2. 山西省高等学校优秀创新团队项目，2015-0101，2015年度山西省高等学校优秀创新团队，2016/01-2018/12，100万元，结题，参加；
3.山西省回国留学人员科研资助重点项目，2015-重点3，食管癌分子分型及耐药特异分子标记的筛选鉴定，2015/01-2018/12，30万元，结题，参加；
4.国家自然科学基金重点项目，81330063，食管鳞癌异质性及耐药机制的多组学贯穿分析研究，2014/01-2018/12，290万元，结题，参加；
6.山西省科技创新团队项目，2013-23，消化系统恶性肿瘤防治创新团队，2014/01-2015/12，20万元，结题，参加；
7.国家自然科学基金面上项目，81272694，ECRG2 基因在食管癌等常见恶性肿瘤中的突变、功能分析及临床意义评价， 2013/1-2016/12 ，55万元，结题，主持；
8.山西省重点学科建设专项经费，晋财教[2012]143号，恶性肿瘤发病机制、早期诊断标记物及靶向治疗，2013/01-2015/12，160万元，结题，参加。
9.国家自然科学基金面上项目，81071625，食管癌相关基因2在肿瘤形成、转移、治疗中的作用及最小功能结构域的鉴定， 2011/01-2013/12，31万元，结题，主持；
10. 山西省强校工程高等学校优秀青年学术带头人支持计划，晋教科[2008]3号，食管癌相关基因研究， 2009/1- 2011/12 ，20万元，结题，主持；
代表性研究成果和学术奖励情况（每项均按时间倒序排序）
一、期刊论文
1.通信作者论文（勿与第一作者论文重复）
(1)Yu Qian#, Xiao Liang#, Pengzhou Kong#, Yikun Cheng, Heyang Cui, Ting Yan, Jinghao Wang, Ling Zhang,Yiqian Liu, Shiping Guo,Xiaolong Cheng*and Yongping Cui*, Elevated DHODH expression promotes cellproliferation via stabilizing β-catenin in esophagealsquamous cell carcinoma, Cell Death and Disease,2020 11:862
(2)Ling Zhang#, Yingzhen Gao#, Xiaojuan Zhang#, Min Guo#, Jie Yang#, Heyang Cui, Pengzhou Kong,Xia Niu, Yanghui Bi, Jing Xu, Ting Yan, Yanchun Ma, Jian Yang, Yu Qian, Fang Wang, Hongyi Li,Feng Liu,Xiaolong Cheng*and Yongping Cui*. TSTA3 facilitates esophageal squamous cell carcinomaprogression through regulating fucosylation of LAMP2and ERBB2,Theranostics,2020; 10(24): 11339-11358
(3) Pengzhou Kong#, Enwei Xu#, Yanghui Bi#, Xiaoqin Xu#, Xue Liu#, Bin Song, Ling Zhang, Caixia Cheng, Ting Yan, Yu Qian, Jian Yang, Yanchun Ma, Heyang Cui, Yuanfang Zhai, Binbin Zou, Xiangchen Liu, Yikun Cheng, Shiping Guo,Xiaolong Cheng*, and Yongping Cui*,Novel ESCC-related gene ZNF750 as potential Prognostic biomarker and inhibits Epithelial-Mesenchymal Transition through directly depressing SNAI1 promoter in ESCC,Theranostics,2020,10(4): 1798-1813.
(4) Yanghui Bi#, Shixing Guo#, Xiaoqin Xu#, Pengzhou Kong#, Heyang Cui#,Ting Yan#,Yanchun Ma#, Yikun Cheng#, Yunqing Chen#, Xue Liu, Ling Zhang, Caixia Cheng, Enwei Xu, Yu Qian, Jian Yang, Bin Song, Hongyi Li, Fang Wang, Xiaoling Hu, Xiangchen Liu, Xia Niu, Yuanfang Zhai, Jing Liu, Yaoping Li,Xiaolong Cheng*, and Yongping Cui*,Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma,Cell Death & Disease,2020, In press.
(5) Ling Zhang#, Xia Niu, Yanghui Bi, Heyang Cui, Hongyi Li, andXiaolong Cheng*,Potential Role of Targeting KDR andProteasome Inhibitors in the Therapy ofEsophageal Squamous Cell Carcinoma,Technology in Cancer Research &Treatment,2020; 19: 1533033820948060
(6)Jian Yang#，Xiao Liang#，Yuanfang Zhai，Xiaoling Hu，Zhiwu Jia，Xiaolong Cheng*,Considering gemcitabine-based combination chemotherapyas a potential treatment for advanced oesophageal cancer: Ameta-analysis of randomised trials,THE INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2020,74(7):e13510
(7)XiaolingHu#,YuanfangZhai#, RuyiShi#, YuQian#, HeyangCui,JieYang, YanghuiBi,TingYan,JieYang,YanhunMa,LingZhang,Yinqian Liu,GuodongLI,MingshengZhang,YongpingCui, PengzhouKong*,XiaolongCheng*, FAT1 inhibits cell migration and invasion via effecting cellular mechanical properties in esophageal squamous cell carcinoma, Oncology reports,2018; 39(5):2136-2146.
(8)RuyiShi#,HeyangCui#,YanghuiBi#,XunHuang#,BinSong,CaixiaCheng,LingZhang,JingLiu,ChantingHe,FangWang,ZhiwuJia,BinYang,JuanWang,JinyaoDong,ZhijieDu,ShuaishuaiXiao,YongpingCui,XiaolongCheng*,Artesunate altered cellular mechanical properties leading to deregulation ofcell proliferation and migration in esophageal squamous cellcarcinoma,Oncology Letters,2015,9(5):2249-2255.
(9)赵志平#，刘静，李曙晶，邹丽，缪小平，成晓龙*，FASL-844T/C多态性与宫颈癌易感性的Meta分析，中国妇幼保健,2013,28(17):2828-2830。
(10)宋彬#，刘静，史卫俊，赵和平，贾军梅，柯俊涛，缪小平，成晓龙*,TOX3
基因单核苷酸多肽与乳腺癌风险的相关性Meta分析,中国药物与临床,2013,13(10):1252-1255。
(11)李曙晶#，张燕燕，刘静，张玲，师如意，赵志平，贺婵婷，成晓龙*，癌基因B-RafV600E导致黑色素瘤Sbcl2和SK-MEL31细胞染色体不稳定性的分子机制研究，肿瘤研究与临床，2012,24(9):589-592。
(12)马林梅#，刘静，李曙晶，史卫俊，邹丽，缪小平，成晓龙*，FAS-670A/G多态性与宫颈癌易感性的Meta分析，中国优生与遗传杂志，2012,(04):29-31。
(13)景永茂#，刘静，李曙晶，史卫俊，成晓龙*，COX-2启动子区遗传变异与胃癌发病风险的关系，中国优生与遗传杂志，2012,(05):24-25。
(14)刘静#，李曙晶，史卫俊，成晓龙*，凋亡通路Fas/Fasl遗传变异与胃癌发病
风险的关系，中国优生与遗传杂志，2012,(08):28-30。
2.第一作者论文
(1)Jing Liu#, Yanyan Zhang#,Xiaolong Cheng#, Shujing Li, Heyang Cui,LingZhang,RuyiShi,ZhipingZhao,ChantingHe,ChuanguiWang, HaoliangZhao,CeZhang,Fisk HA,Guadagno TM,YongpingCui*,Phosphorylation ofMps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosomeinstability in melanoma,Oncogene,2013,32:713-723.
(2)XiaolongCheng#,Shih-HsinLu,YongpingCui*,ECRG2 regulatesECM degradation and uPAR/FPRL1 pathway contributing cellinvasion/migration，Cancer Letters,2010,290(1):87-95.
(3)Xiaolong Cheng#*,HuapingZhang,DongxingGuo,ZhongdongQiao,UPREGULATION OF FAS AND FASL EXPRESSION IN NICOTINE-INDUCED APOPTOSIS OFENDOTHELIAL CELLS，Methods and Findings in Experimental and ClinicalPharmacology,2010,32(1):13-18.
(4)Xiaolong Cheng#,ZhengShen,LitianYin,Shih-HsinLu,YongpingCui*,ECRG2 Regulates Cell Migration/Invasion through Urokinase-typePlasmin Activator Receptor (uPAR)/beta 1 Integrin Pathway,Journal ofBiological Chemistry.2009,284(45):30897-30906.
(5)XiaolongCheng#,ZhengShen,JianyiYang,Shih-HsinLu,YongpingCui*,ECRG2 disruption leads to centrosome amplification and spindlecheckpoint defects contributing chromosome instability,Journal of BiologicalChemistry,2008,283(9):5888-5898.
3.既非第一作者又非通信作者论文
(1) Ting Yan#，Heyang Cui#，Yong Zhou#，Bin Yang#，Pengzhou Kong#，Yingchun Zhang#，Yiqian Liu，Bin Wang，Yikun Cheng，Jiayi Li，Shixing Guo，Enwei Xu，Huijuan Liu，Caixia Cheng，Ling Zhang，Ling Chen，Xiaofei Zhuang，Yu Qian，Jian Yang，Yanchun Ma，Hongyi Li，Fang Wang，Jing Liu，Xuefeng Liu，Dan Su，Yan Wang，Ruifang Sun，Shiping Guo，Yaoping Li，Xiaolong Cheng，Zhihua Liu，Qimin Zhan*，and Yongping Cui*.Multi-region sequencing unveils novel actionable targets and spatial heterogeneity in esophageal squamous cell carcinoma. Nature Communications. 2019, Apr 11;10(1):1670.
(2)Yanchun Ma#，Yi Wang#，Lu Wang，Yu Qian，Jian Yang，Pengzhou Kong，Ting Yan，Hongyi Li，Fang Wang，Xiaolong Cheng，Yongping Cui*.Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway. Eur J Pharmacol. 2019 May 15;851:43-51.
(3)Yanghui Bi#, Pengzhou Kong#, Ling Zhang#, Heyang Cui#, Xiaoqin Xu#, Feiyun Chang#, Ting Yan, Jiayi Li, Caixia Cheng, Bin Song, Xia Niu, Xiangchen Liu, Xue Liu, Enwei Xu, Xiaoling Hu, Yu Qian, Fang Wang, Hongyi Li, Yanchun Ma, Jian Yang, Yiqian Liu, Yuanfang Zhai, Yi Wang, Yingchun Zhang, Haiyan Liu, Jing Liu, Jintao Wang*,Yongping Cui,Xiaolong Cheng. EP300 as an oncogene correlates with poor prognosis in esophageal squamous carcinoma.J Cancer. 2019 Aug 29;10(22):5413-5426.
(4)JieYang#, PengzhouKong#, JianYang#, ZhiwuJia#, XiaolingHu, Zianyi Wang, HeyangCui, YanghuiBi, YuQian, Hongyi Li,Fang Wang, Bin Yang, Ting Yan, Yanchun Ma, Ling Zhang, Caixia Cheng, Bin Song, Yaoping Li, Enwei Xu, Haiyan Liu, Wei Gao, Juan Wang, Yiqian Liu, Yuanfang Zhai, , Lu Chang, Yi Wang, Yingchun Zhang, Ruyi Shi, Jing Liu, Qi Wang,Xiaolong Cheng, Yongping Cui*,High TSTA3 Expression as a Candidate Biomarker for Poor Prognosis of Patients With ESCC, Technology Cancer Research&Treatment, 2018,17:1-9.
(5)YikeLi#, YanyanZhang#, ShuaishuaiXiao, PengzhouKong,CaixiaCheng, RuyiShi, FangWang, LingZhang, JuanWang, ZhiwuJia, ShuaiWu, YunLiu, JianshengGuo,XiaolongCheng, YongpingCui*, JingLiu*, Mps1 is associated with the BRAFV600E mutation but does not rely on the classic RAS/RAF/MEK/ERK signaling pathway in thyroid carcinoma, Oncology Letters, 2018;15(6):9978-9986.
(6)BinYang#, TingYan#, HeyangCui#, EnweiXu#, YanchunMa#, CaixiaCheng#, LingZhang, PengzhouKong, FangWang, YuQian, JianYang, YaopingLi, HongyiLi, YanghuiBi, XiaolingHu, JuanWang, BinSong, JieYang, WeiGao, JingLiu, BinbinZou, RuyiShi, YanyanZhang, HaiyanLiu, YiqianLiu, YuanfangZhai, LuChang, YiWang, YingchunZhang, ZhiwuJia, XingChen, YanfengXi, GuodongLi, JianfangLiang, JianshengGuo, ShipingGuo, RongshengZhang,XiaolongCheng, YongpingCui*, The macro-evolutionary events in esophageal squamous cell carcinoma. Oncotarget, 2017; 8(68):112770-112782.
(7)XiaolingHu#, YuanfangZhai#, PengzhouKong#, HeyangCui#, TingYan, JianYang,YuQian , YanchunMa,FangWang , HongyiLi, CaixiaCheng, LingZhang, ZhiwuJia, YaopingLi, BinYang, EnweiXu, JuanWang , JieYang,YanghuiBi ,LuChang , YiWang, YingchunZhang, BinSong, GuodongLi, RuyiShi, Jing Liu, MingshengZhang,XiaolongCheng, YongpingCui*, FAT1 prevents epithelial mesenchymal transition (EMT) via MAPK/ERK signaling pathway in esophageal squamous cell cancer, Cancer letters, 2017; 397:83-93.
(8)Caixia Cheng#,YongZhou#,HongyiLi#,TengXiong#,ShuaichengLi#,YanghuiBi#,PengzhouKong,FangWang,HeyangCui,YaopingLi,XiaodongFang,TingYan, YikeLi,JuanWang,BinYang,LingZhang,ZhiwuJia,BinSong,XiaolingHu,JieYang,HaileQiu,GehongZhang,JingLiu,EnweiXu,RuyiShi,YanyanZhang, Haiyan Liu,ChantingHe,ZhenxiangZhao,YuQian,RuizhouRong,ZhiweiHan,YanlinZhang,WenLuo,JiaqianWang,ShaoliangPeng,XukuiYang,XiangchunLi, LinLi,HuFang,XingminLiu,LiMa,YunqingChen,ShipingGuo,XingChen,YanfengXi,GuodongLi, Jianfang Liang,XiaofengYang,JianshengGuo,JunMeiJia,QingshanLi,XiaolongCheng,QiminZhan*,YongpingCui*,Whole-Genome Sequencing Reveals Diverse Models of StructuralVariations in Esophageal Squamous Cell Carcinoma,American Journal of HumanGenetics,2016,98(2):256-274.
(9)Bin Song#,HeyangCui#,YaopingLi#,CaixiaCheng#,BinYang#,FangWang#,PengzhouKong#,HongyiLi,LingZhang,ZhiwuJia,YanghuiBi,JiaqianWang,YongZhou,JingLiu,JuanWang,ZhenxiangZhao,YanyanZhang,Xiaoling Hu, RuyiShi, JieYang,HaiyanLiu,TingYan,YikeLi,EnweiXu,YuQian,YanfengXi,ShipingGuo ,YunqingChen,JinfenWang,GuodongLi,JianfangLiang,JunmeiJia,XingChen,JianshengGuo,TongWang,YanboZhang,QingshanLi,ChuanguiWang,XiaolongCheng,QiminZhan*,Yongping Cui*,Mutually exclusive mutations in NOTCH1 and PIK3CA associated with clinicalprognosis and chemotherapy responses of esophageal squamous cell carcinoma inChina，Oncotarget，2016，7（3）：3599-3613.
(10)Caixia Cheng#,HeyangCui#,Ling Zhang#,ZhiwuJia#,BinSong#,FangWang#,YaopingLi,JingLiu,PengzhouKong,RuyiShi,YanghuiBi,BinYang, JuanWang,ZhenxiangZhao,YanyanZhang,XiaolingHu,JieYang,ChantingHe, ZhipingZhao,JinfenWang,YanfengXi,EnweiXu,GuodongLi,ShipingGuo,YunqingChen,XiaofengYang,XingChen,JianfangLiang,JianshengGuo,XiaolongCheng,ChuanguiWang,QiminZhan*,YongpingCui*,Genomicanalyses reveal FAM84B and NOTCH pathway relate to the progression ofesophageal squamouscell carcinoma,GigaScience,2016,5(1):1-13.
(11)Ling Zhang#,YongZhou#,CaixiaCheng#,HeyangCui#,LeCheng#,PengzhouKong#,JiaqianWang#,YinLi#,WenliangChen,BinSong,FangWang,ZhiwuJia,LinLi,YaopingLi,Bin Yang,JingLiu,RuyiShi,YanghuiBi,Yanyan Zhang,JuanWang,ZhenxiangZhao,XiaolingHu,Jie Yang,HongyiLi,ZhiboGao,GangChen,XuanlinHuang,XukuiYang,ShengqingWan,ChaoChen,BinLi,Yongkai Tan,LongyunChen,MinghuiHe,ShaXie,XiangchunLi,XuehanZhuang,MengyaoWang,ZhiXia, LonghaiLuo,JieMa,BingDong,JiuzhouZhao,YongmeiSong,YunweiOu,EnmingLi,LiyanXu,JinfenWang,YanfengXi,GuodongLi,EnweiXu,JianfangLiang, XiaofengYang,JianshengGuo,XingChen,YanboZhang,QingshanLi,LixinLiu,YingruiLi,XiuqingZhang,Huanming Yang,DongxinLin,XiaolongCheng,YongjunGuo,JunWang,QiminZhan*,Yongping Cui*,Genomic analyses reveal mutationalsignatures and frequently altered genes in esophageal squamous cellcarcinoma,American Journal of HumanGenetics,2015,96(4):597-611.
(12)Ling Zhang#,RuyiShi#,ChantingHe#,CaixiaCheng,BinSong,HeyangCui, YanyanZhang,ZhipingZhao,YanghuiBi,XiaofengYang,XiaopingMiao,JianshengGuo,XingChen,JinfenWang,YaopingLi,XiaolongCheng,JingLiu*,YongpingCui*,Oncogenic,B-Raf(V600E)abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells,CancerLetters,2013,337(1):125-132.
(13) LiLu#*,HuifangSong,WeiguoZhang,XueqinLiu,QianZhu,XiaolongCheng, GuiJiaoYang,AngLi,ZhichengXiao*,Potential role of 20Sproteasome in maintaining stem cell integrity of human bone marrow stromalcells in prolonged culture expansion,Biochemical and Biophysical ResearchCommunications,2012,422(1):121-127.
(14)YongpingCui#*,XiaolongCheng,CeZhang,YanyanZhang,ShujingLi,ChuanguiWang,GuadagnoThomas M,Degradation of the Human MitoticCheckpoint Kinase Mps1 Is Cell Cycle-regulated by APC-c(Cdc20) and APC-c(Cdh1)Ubiquitin Ligases,Journal of BiologicalChemistry,2010,285(43):32988-32998.
(15)ZiYan#,FengLiang#,LiGuo,JinWang,XiaoliangWang,XiaolongCheng,XinliangMa,HuirongLiu*,Myeloperoxidase increasedcardiomyocyte protein nitration in mice subjected to nonlethal mechanicaltrauma,Biochemical and Biophysical ResearchCommunications,2010,393(3):531-535.
获得学术奖励
成晓龙（6/7），食管鳞癌遗传变异的分析鉴定及癌变机制研究，中国抗癌协会，2017年度中国抗癌协会科技奖，二等奖，2018
（崔永萍、阎婷、孔鹏洲、张玲、程彩霞、成晓龙、钱钰）
成晓龙，国家自然科学基金委员会荣誉证书，2016
