标志性成果 |
1. 科研项目 [1] 国家自然科学基金委员会, 青年科学基金项目, 82204022, 高盐膳食上调TMEM16A介导肌浆网RyR2异常磷酸化在冠 状动脉重构中的作用机制研究, 2023-01-01 至 2025-12-31, 30万元, 在研, 主持 [2] 国家卫生健康委员会尘肺病重点实验室 2023 年度开放课题面上项目, NHC202307,杜鹃素下调缝隙连接蛋白 Cx43 改善二氧化硅致肺动脉重塑的机制研究,2024-01-01 至 2025-12-31, 10万元, 在研, 主持 [3] 山西省科技厅, 山西省自然科学研究面上项目, 202103021224227, ANO1介导肌浆网RyR2磷酸化在高盐 膳食致冠状动脉重构中的调控机制, 2022-01 至 2024-12, 10万元, 已结题,主持 [4] 山西省留学人员管理办公室, 山西省回国留学人员科研资助项目, 2020-075, 基于钙激活氯通道研究 杜鹃素防治盐敏感高血压冠脉重构的机制, 2020-08 至 2023-07, 5万元, 已结题,主持 2. 学术论文 [1] XIAOMIN HOU XIAOJIANG QIN; QINGSHAN LI*; Structure-activity associations in novel farrerol derivatives with vasorelaxant properties, Mol Med Rep, 2018, 18(5): 4709-4715. [2] Xiaomin Hou; Yu Liu; LonggangNiu; Lijuan Cui; Mingsheng Zhang*; Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery, Planta Med, 2014, 80(6): 465-472. [3] Xinrong Xu#, Xiaomin Hou# (共同第一作者), Ye Xing, Tianfeng Feng, Lina Chai, Yunting Guo, Liangjing Chen, Yiwei Shi, Xiaojiang Qin*. Dibazol-induced relaxation of ophthalmic artery in C57BL/6J mice is correlated with the potency to inhibit voltage-gated Ca2+ channels. Exp Eye Res. 2023, 231: 109468. [4] Xiaojiang Qin, Xiaomin Hou, Xinrong Xu, Liangjin Chen, Anqi Gao, Yuxuan Hao, Xufeng Du, Liangyuan Zhao, Yiwei Shi, Qingshan Li*. Down-regulation of connexin 43 contributes to structure and function of pulmonary artery in nicotine-administered mice. Toxicol Lett. 2023,377(15): 1-13. [5] Xiaojiang Qin,Anqi Gao,Xiaomin Hou,Xinrong Xu,Liangjin Chen,Lin Sun,Yuxuan Hao,Yiwei Shi. Connexins may play a critical role in cigarette smoke-induced pulmonary hypertension. Arch Toxicol. 2022,12(04): 308-312. [6] Xiaojiang Qin#; Xiaomin Hou#(共同第一作者); Kun Zhang; Qingshan Li*; α1D-adrenoceptor involves the relaxation effect of farrerol in rat aortic vascular smooth muscle cells, Eur J Pharmacol, 2019, 853:169-183. [7] Xiaojiang Qin#; Xiaomin Hou#(共同第一作者); Kun Zhang; Qingshan Li*; Farrerol Modulates Aorta Gene Expression Profile in Spontaneously Hypertensive Rats, Planta Med, 2018, 84(5): 296-303. [8] Xiaojiang Qin; Xinrong Xu; Xiaomin Hou; Ruifeng Liang; Liangjing Chen; Yuxuan Hao; Anqi Gao; Xufeng Du; Liangyuan Zhao; Yiwei Shi; Qingshan Li*; The pharmacological properties and corresponding mechanisms of farrerol: a comprehensive review, PharmBiol, 2021, 60(1): 9-16. [9] YANG R, LIU Y, HOU X(侯晓敏), Fan Y, Li J, Chen M, Wang Y, Zhang X, Zhang M. MAPKs-mediated modulation of the myocyte voltage-gated K(+) channels is involved in ethanol-induced rat coronary arterial contraction. Eur J Pharmacol, 2018, 834: 274-80. [10] 侯晓敏,施熠炜,孙琳,赵旭,郑志发,常铭洋,张明升,秦小江(通讯作者). 高盐饮食上调跨膜蛋白16A致C57BL/6J小鼠脑动脉重构的机制. 中国药理学通报. 2023,39(06): 1042-1047. [11] 侯晓敏, 张明升, 秦小江. 杜鹃素通过增强Kv1.5和Kv2.1表达抑制尼古丁所致的肺动脉平滑肌细胞增殖. 中国病理生理杂志, 2019, 35(07): 1276-82. [12] 侯晓敏, 秦小江, 张明升. 槲皮素对自发性高血压大鼠大脑中动脉张力与缝隙连接蛋白43表达的影响. 中国临床药理学杂志, 2018, 34(24): 2821-4. 3. 科技奖励 [1] 侯晓敏(1/3); 《Structure-activity associations in novel farrerol derivatives with vasorelaxant properties》, 太原市科学技术协会, 自然科学, 其他, 2019(侯晓敏侯晓敏; 秦小江; 李青山) (科研奖励科研奖励,二等奖) 4. 发明专利 [1] 李青山; 秦小江; 侯晓敏; 韩玲革; 班树荣; 石磊。杜鹃素与其衍生物及其可药用盐在制备由血管收缩引起的心脑血管疾病药物中的应用。(专利号:ZL201110303137.0) [2] 侯晓敏;秦小江;郭戍辰;施熠炜;聂继盛;陈亮京;郝雨萱;葛帅帅;马雁军。一种高效快速培养小鼠原代肺动脉内皮细胞培养基的制备及应用。(申请号:202310131063.X) |