闫超群
博士，硕士生导师，临床药学教研室副教授
E-mail: chaoqun@sxmu.edu.cn
教育经历
2015年9月—2020年6月 山西医科大学，临床药学，博士
2012年9月—2015年6月 山西医科大学，药物化学，硕士
2008年9月—2012年6月 山西医科大学，药学，学士
工作经历
2020年9月—至今 山西医科大学，药学院，讲师
荣誉获奖
2024年度山西医科大学青年教师教学竞赛决赛（医科组）三等奖
2024年度山西医科大学大学生创新大赛三等奖（指导教师）
2024年度山西医科大学青年教师教学竞赛药学院一等奖
2020年度校级优秀研究成果期刊论文类三等奖
教学情况
研究生课程《高等临床药学》负责人，讲授《药物治疗学》《生物药剂学》《药事管理》《药物流行病学》等课程。
研究领域
主要从事天然来源活性小分子化合物的结构优化、特异性亲和蛋白筛选、小分子化合物与蛋白相互作用机制及相关理论化学计算、基于小分子化合物特异性亲和蛋白的生物活性作用机制研究。
代表性科研、教改项目
1、国家自然科学基金委员会，青年科学基金项目，82104171，杜鹃素靶向调控GSK3β/Nrf2介导的铁死亡改善血栓闭塞性脉管炎内皮损伤的机制研究，2022-01至2024-12，30万元，结题，主持。
2、山西省教育厅，2021年山西省高等学校科技创新项目，杜鹃素靶向调控GSK3β/AMPK介导的自噬改善血栓闭塞性脉管炎内皮损伤的机制研究，2022-01至2023-12，2万元，结题，主持。
3、山西省科技厅，2021年山西省基础研究计划（自由探索类）项目，杜鹃素靶向调控GSK3β/Nrf2介导的铁死亡改善血栓闭塞性脉管炎内皮损伤的机制研究，2022-01至2024-12，4万元，在研，主持。
4、山西省教育厅，山西省研究生教育创新项目，2017BY084，杜鹃素内皮细胞保护作用靶点的初步研究，2017-06至2020-06，1万元，结题，主持。
代表性论著
1、Minfan Pei#, Aiyun Qian#, Li Cao, Zhenfang Wang, Yiping Lu, Chaoqun Yan*, Taigang Liang*. In silico design of novel potential isonicotinamide-based glycogen synthase kinase-3β (GSK-3β) inhibitors: 3D-QSAR, molecular docking, molecular dynamics simulation and ADMET studies. [J]. New Journal of Chemistry. 2025.
2、Liwei Wang, Lu Zhang, Yang Yun, Tingting Liang, Chaoqun Yan, Zhuoya Mao, Jingfang Zhang, Baoshe Liu*, Jian Zhang, Taigang Liang*. Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control. [J]. Molecular and Cellular Biochemistry (2024): 1-17.
3、Yidan Sun, Chaoqun Yan, Tingting Liang, Wen Li, Minfan Pei, Linyan Zhang, Qingshan Li, Taigang Liang*. Comparative study on interactions of phillyrin and phillygenol with lysozyme: Spectroscopy, differential scanning calorimetry and molecular modeling approaches. [J]. Journal of Molecular Liquids, 2024: 124571.
4、Chungiang Wang, Yuzhu Fan, Minfan Pei, Chaoqun Yan, Taigang Liang*, 3D and 2D-QSAR Studies on Natural Flavonoids for Nitric Oxide Production Inhibitory Activity. [J]. Letters in Drug Design & Discovery, 2024.
5、梁婷婷，张璐，闫超群，梁泰刚*.N-取代马来酰亚胺类hMGL抑制剂的3D-QSAR、分子对接和分子动力学研究. [J]. 化学通报, 2024.
6、Dongxiao Cui, Dingqiao Xu, Shijun Yue, Chaoqun Yan, Wenjuan Liu, Ruijia Fu, Wenfu Ma, Yuping Tang. Recent advances in the pharmacological applications and liver toxicity of triptolide[J]. Chemico-Biological Interactions, 2023: 110651.
7、Junqiu Miao, Jing Shen, Chaoqun Yan, Jinhong Ren, Haixin Liu, Yuanbiao Qiao, Qingshan Li*. The protective effects of Mai-Luo-Ning injection against LPS-induced acute lung injury via the TLR4/NF-κB signalling pathway. [J]. Phytomedicine, 2022,104, 154290.
8、Wen Li, Yuzhu Fan, Chaoqun Yan, YanDu, Tingting Liang, Chunqiang Wang, Liwei Wang, Lingling Han, Qingshan Li*, Taigang Liang*. Triptolide and Methotrexate Binding Competitively to Bovine Serum Albumin: A Study of Spectroscopic Experiments, Molecular Docking, and Molecular Dynamic Simulation[J]. Journal of Molecular Liquids, 2022,367:120300.
9、Liwei Wang, Zhiyu Duan, Madan Liang, Chunqiang Wang*, Tingting Liang, Liqian Sun, Chaoqun Yan, Qingshan Li*, Taigang Liang*. A pivotal role of selective autophagy in mitochondrial quality control: Implications for zinc oxide nanoparticles induced neurotoxicity[J]. Chemico-Biological Interactions, 2022,363: 110003.
10、Zhiyu Duan, Madan Liang, Congcong Yang, Chaoqun Yan, Liwei Wang, Jiaqi Song, Lingling Han, Yuzhu Fan, Wen Li, Taigang Liang*, Qingshan Li*. Selenium nanoparticles coupling with Astragalus Polysaccharides exert their cytotoxicities in MCF-7 cells by inhibiting autophagy and promoting apoptosis[J]. Journal of Trace Elements in Medicine and Biology, 2022: 127006. 2022,73: 127006
11、Lingling Han, Jiaqi Song, Chaoqun Yan, Chunqiang Wang, Liwei Wang, Wen Li, Yan Du, Qingshan Li*, Taigang Liang*. Inhibitory activity and mechanism of calycosin and calycosin-7-O-β-D-glucoside on α-glucosidase: Spectroscopic and molecular docking analyses[J]. Process Biochemistry, 2022. 2022,118:227-235.
12、Chaoqun Yan, Jiali Zhang, Taigang Liang*, Qingshan Li*. Diorganotin (IV) complexes with 4-nitro-N-phthaloyl-glycine: Synthesis, characterization, antitumor activity and DNA-binding studies. [J]. Biomedicine & Pharmacotherapy, 2015, 71: 119-127.
13、Xiaoyan Zhang1, Taigang Liang1, Wanxia Yang, Lanfang Zhang, Shuting Wu, Chaoqun Yan, Qingshan Li*. Astragalus membranaceus injection suppresses production of interleukin-6 by activating autophagy through the AMPK-mTOR pathway in lipopolysaccharide-stimulated macrophages[J]. Oxidative medicine and cellular longevity, 2020, 2020.
14、Dongxiao Cui, Chaoqun Yan, Junqiu Miao, Xiaoyan Zhang, Jingrun Chen, Liqian Sun, Liqiang Meng, Taigang Liang*, Qingshan Li*. Synthesis, characterization and antitumor properties of selenium nanoparticles coupling with ferulic acid. [J]. Materials Science & Engineering C, 2018, 90: 104-112.
15、Liqiang Meng, Liqian Sun, Chaoqun Yan, Dongxiao Cui, Jingrun Chen, Taigang Liang*, Qingshan Li*. 3D QSAR studies of tricyclic compounds as Porcupine Inhibitors for Wnt pathway inhibitory activity. [J]. Letters in Drug Design & Discovery, 2018, 15(7): 721-732.
16、Liqian Sun, Liqiang Meng, Chaoqun Yan, Dongxiao Cui, Junqiu Miao, Jingrun Chen, Taigang Liang*, Qingshan Li*. 3D-QSAR Studies on 4-([1,2,4]Triazolo[1,5-α]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole Analogues as Potent Inhibitors of Transforming Growth Factor-β Type I Receptor Kinase. [J]. Chinese Journal of Structural Chemistry, 2018, 37(4): 517-530.
17、Xiaorui Wang, Junqiu Miao, Chaoqun Yan, Rui Ge, Taigang Liang*, Enli Liu, Qingshan Li*. Chitosan attenuates dibutyltin-induced apoptosis in PC12 cells through inhibition of the mitochondria-dependent pathway. [J]. Carbohydrate Polymers, 2016, 151: 996-1005.
18、Taigang Liang#, Chaoqun Yan#, Li Yang, Mengnan Hu, Shurong Ban, Qingshan Li*. 3D-QSAR studies of 8-substituted chromen-4-one-2-carboxylic acid derivatives as potent agonists for the orphan G protein-coupled receptor 35. [J]. Medicinal Chemistry Research, 2015, 24(5): 2183-2194.
