畅瑞苗
医学博士学位，副教授，硕士生导师，药物分析教研室
E-mail: chang5013@126.com
教育经历
2013年9月—2016年12月 西安交通大学，博士
2010年9月—2013年7月 山西医科大学，硕士
2006年9月—2010年7月 山西医科大学，学士
工作经历
2023年12月—今 山西医科大学 副教授
2022年3月—今 山西白求恩医院 博士后
2016年12月—2023年12月 山西医科大学 讲师
学术任职
杂志《西北药学》、《Nano Biomedicine and Engineering》青年编委。
荣誉获奖
全国医学类微课教学比赛三等奖。
教学情况
主要承担研究生《现代药物分析方法与技术》、本科生《药物分析》理论及实验课程、本科生《中药制剂分析》实验课程、药学专升本《药物分析》理论课程的教学。
研究领域
主要从事基于miRNA中药活性成分筛选及心肾药效研究、中药活性成分分离分析、难溶性药物增溶等方面的科研工作。
代表性科研、教改项目
1、黄芪调控miR-21活性物质的快速发现及其对心肌纤维化ERK-MAPK通路的影响，中国博士后科学基金第73批面上资助，8万元。项目负责人，在研。
2、黄芪中靶向miR-21成熟过程关键核酸的活性成分快速发现及其抗心衰作用研究，国家自然科学基金（青年），30万元。项目负责人，在研。
3、以mi-RNA 21为靶点的黄芪抗心衰活性组分可视化垂钓新方法构建。山西省基础研究计划，5万元。项目负责人，结题。
4、山西医科大学教育教学研究课题，一般性课题：基于OBE理念的药学本科毕业论文指导方法研究与实践，项目负责人，在研。
5、环境暴露微血管病变防治，山西省科技创新人才团队（青年），100万元。项目核心人员，在研。
6、基于新型“双增敏”策略的样品前处理技术耦合SFC-MS的FAHFAs分析体系构建，山西省基础研究计划面上项目，10万元。项目核心人员，在研。
7、基于新型功能化离子液体的HPCE分离体系研究及其在临床手性药物分析中的应用，山西省卫生健康委员会医学重点科技项目，15万元。项目核心人员，结题。
代表性论著
1. Ruimiao Chang#, Xinying Qu#, Yuting Ye, Ying Qu, Bingyang Chu*, Zhiyong Qian*. Current advances in nanomedicine-based therapies for acute kidney injury. Chinese Chemical Letters, 2024, 394, 110802.
2. Ruimiao Chang, Huichun Wang, Shumian Liu, Yijing Dong, Guangbin Zhang, Anjia Chen, Ruiping Zhang*, Yong Li*. Modifying of magnetic UiO-66-NH2 as a new nanosorbent by thermo-alkali-hydrolysis technology for highly efficient enrichment and determination of quercetin in apple peel[J]. Separation and Purification Technology, 2025, 353: 128054.
3. Meiyi Wang, Junzhao Ren, Guangbin Zhang, Hongfen Zhang, Ruimiao Chang, Haixia Yu*, Anjia Chen*. Simultaneous separation and determination of seven biphenyl cyclooctene lignans in Schisandra chinensis and its preparations by micellar electrokinetic chromatography with dual organic solvent system[J]. Phytochemical Analysis, 2024;1-10.
4. 畅瑞苗, 张艳洋, 康安娟, 张广彬, 余彦平, 任俊照, 陈安家, 李勇. 热碱解改性UiO-66材料对槲皮素的装载、释放及抗氧化作用研究[J]. 药学学报, 2023, 58(9): 2802-2810.
5. Rui Miao Chang, Yan Yang Zhang, Guang Bin Zhang, Xiao Xia Zhang, An Jia Chen, Wen Zhang, Yong Li. Application of thermal alkaline hydrolysis technology to improve the loading and in-vitro release of gallic acid in UiO-66[J]. Food Chemistry, 2022, 391: 133238.
6. Hua Wang#, Yuhang Yang#, Jing Guo, Mengli Wang, Hongfen Zhang, Guangbin Zhang, Ruimiao Chang*, Anjia Chen*. Simultaneous separation and determination of four active ingredients in Picria fel-terrae Lour. and its preparations by micellar electrokinetic chromatography[J]. Phytochemical Analysis, 2021, 32(6): 1110-1117.
7. Yang Yuhang#, Wang Hua#, Yu Haixia, Zhang Hongfen, Zhang Guangbin, Chang Ruimiao*, Chen Anjia*. Simultaneous separation and determination of three huperzine alkaloids in Huperzia serrata and its preparations by cyclodextrin-modified mixed micellar electrokinetic capillary chromatography[J]. Analytical Biochemistry, 2021, 623: 114207.
8. Mengli Wang, Jing Guo, Zhiying Wang, Guangbin Zhang, Haixia Yu, Ruimiao Chang*, Anjia Chen*. Simultaneous separation and determination of hirsutine and hirsuteine by cyclodextrin-modified micellar electrokinetic capillary chromatography[J]. Phytochemical analysis. 2020, 31: 112-118.
9. Haitao Guo, Zhiying Wang, Liying Xu, Hongfen Zhang, Ruimiao Chang*, Anjia Chen*. Separation and simultaneous determination of seven bioactive components in, Tripterygium wilfordii, Hook.F. and, Tripterygium, preparations by micellar electrokinetic capillary chromatography[J]. Electrophoresis 2019, 40, 547-554.
10. Jing Guo, Mengli Wang, Haitao Guo, Ruimiao Chang, Haixia Yu, Guangbin Zhang*, Anjia Chen*. Simultaneous separation and determination of seven isoflavones in Radix Puerariae by capillary electrophoresis with a dual cyclodextrin system[J]. Biomedical Chromatography. 2019; e4646.
11. Zhiying Wang, Haitao Guo, Meng Chen, Guangbin Zhang, Ruimiao Chang*, Anjia Chen*. Separation and determination of corynoxine and corynoxine b using chiral ionic liquid and hydroxypropyl-β-cyclodextrin as additives by field-amplified sample stacking in capillary electrophoresis[J], Electrophoresis, 2018, 39(17): 2195-2201.
12. Ruimiao Chang, Qiang Fu, Yong Li, Mingchan Wang, Wei Du, Chun Chang, Aiguo Zeng*. Crystallization and relaxation dynamics of amorphous loratadine under different quench-cooling temperatures[J]. CrystEngComm, 2017, 19(2): 335-345.
13. Ruimiao Chang, Qiang Fu, Pei Yu, Lu Wang, Wei Du, Chun Chang, Aiguo Zeng*. A new polymorphic form and polymorphic transformation of loratadine[J]. RSC Advances, 2016, 6(88): 85063-85073.
14. Ruimiao Chang, Aiguo Zeng, Wei Du, Xinya Xu, Saijie Zuo, Chun Chang, Qiang Fu*. An HPLC method for the determination of a novel anti-hypertension agent 6,7-dimethoxy-3-(4-(4-fluorobenzyloxy)-3-methoxyphenylmethyl) quinazolin-4(3H)-one in rat plasma: application to pharmacokinetic study[J]. Biomedical Chromatography, 2016, 30(7): 1118-1123.
15. Chen M, Chang RM, Xu LY, Huang YY, Zhang HF*, Chen AJ*. Simultaneous separation and determination of praeruptorin A, B and C by micellar electrokinetic chromatography using sodium dodecyl sulfate and sodium cholate as mixed micelles[J]. Phytochemical Analysis, 2018, 29(5): 425-431.
16. Xu LY, Chang RM, Chen M, Li L, Huang YY, Zhang HF*, Chen AJ*. Quality evaluation of Guan-Xin-Ning injection based on fingerprint analysis and simultaneous separation and determination of seven bioactive constituents by capillary electrophoresis[J]. Electrophoresis, 2017, 38(24): 3168-3176.
17. Wang J, Chang RM, Zhang JY, Zhang T, Fu Q, Chang C, Zeng AG*. Coamorphous loratadine-citric acid system with enhanced physical stability and bioavailability[J]. AAPS PharmSciTech, 2017: 1-10.
