梁泰刚
教授，博士生导师，山西医科大学药学院副院长，药学国家一流专业建设点负责人，药物合成与制剂新技术山西省重点实验室主任，山西省“1331工程”重点创新团队负责人，山西省特色药物研制产教融合研究生联合培养基地负责人，《药物化学》山西省一流建设课程负责人。
个人主页或网站：https://www.researchgate.net/profile/Taigang-Liang
E-mail:ltaigang@163.com
教育经历
2007年9月—2011年6月 山西医科大学，博士
2000年9月—2003年7月 山西医科大学，硕士
1996年9月—2000年7月 山西医科大学，学士
工作经历
2019年12月-今 山西医科大学药学院，副院长，博士生导师，教授
2017年02月-2019年12月 山西省繁峙县科技副县长（挂职）
2015年12月-2017年02月 山西医科大学药学院，教授
2010年12月-2015年12月 山西医科大学药学院，副教授
2003年03月-2010年12月 山西医科大学药学院，助教、讲师
学术任职
山西省药师协会副会长，山西省药学会药物化学专业委员会主任委员。
荣誉获奖
山西省高等学校优秀青年学术带头人，山西省高等学校“131领军人才”、“三晋英才”。获山西省科学技术奖二等奖4项，山西省高校科技进步一等奖4项。指导研究生荣获第六届中国国际“互联网＋”大学生创新创业大赛红旅赛道银奖和先进集体奖，第十二届“挑战杯”中国大学生创业计划竞赛银奖。
教学情况
《药物化学前沿导论》获批全国药学专业学位研究生精品课程，《药物化学》获批山西省一流课程，副主编《药物化学》教材一部。
研究领域
药物合成与作用机制、计算机（AI）辅助药物设计及中药产业化研究。
代表性论著
[1]Liwei Wang, Wei Zhang, Zhenfang Wang, Weiqian Zhang, Lu Zhang, Jiankuan Li, Zhuoya Mao, Jingfang Zhang, Tingting Liang, Rui Ge, Yu Zhang*, Chaoqun Yan*, Jian Zhang,Taigang Liang*. Astragalus Polysaccharide Alleviated Septic Associated Acute Kidney Injury Through Dual Mechanisms of RIPK1-Dependent Necroptosis and Autophagy in Macrophage.[J].Phytotherapy research. 2026.
[2]ZhuoYa Mao*, DeXiang Yan, Su-Fan Zhou, Meng-En Liu, You-Zherui Li,TaiGang Liang*, BangGuo Wei.Chloride-incorporating cascade dearomatization of isoquinolines with chloroformate and DMAD achieving 100% atom economy.[J].Chemical Communications. 2026.
[3]ZhuoyaMao,SufanZhou,PengXiang, DexiangYan,MengenLiu,JunfengChen,JianZhang,TaigangLiang*. Novel Amino Acid-Substituted Cycloastragenol Derivatives with Antibacterial Activity: Design, Synthesis, Structural Characterization, and Molecular Docking.[J].Journal of Molecular Structure. 2025:145160.
[4]Tingli Qu, Nan Zhang, Junjie Cai, Chen Li, Yue Zhang, Xinxue Xu, Shuai Zhang, Wangwei Lv,Liang Taigang*.Integrated bioinformatics and multi-omics reveal Astragalus extract’s gut-kidney axis mechanism in hyperuricemic nephropathy via purine metabolism.[J].Phytomedicine. 2025:157121.
[5]Chunyu Zhang, Fangfang Lai, Hang Gong, Shuying Li, Nan Xiang, Liuyi Que, Nina Xue, Mengyao Hao, Enjia Zhou, Xiaojian Wang,Taigang Liang*, Jing Jin*.A Novel Dual Bruton's tyrosine kinase (BTK)/Janus kinase 3(JAK3) Inhibitor Wj1113 and Its Therapeutic Effects on Rheumatoid Arthritis.[J].Medcomm.2025(7):e70207.
[6]Liwei Wang#, Lu Zhang#, Yang Yun#, Tingting Liang#, Chaoqun Yan, Zhuoya Mao, Jingfang Zhang, Baoshe Liu, Jian Zhang,Taigang Liang*. Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control.[J].Molecular and Cellular Biochemistry. 2025,480(5):3079-3095.
[7]Minfan Pei#, Aiyun Qian#, Li Cao, Zhenfang Wang, Yiping Lu, Chaoqun Yan*,Taigang Liang*.In silico design of novel potential isonicotinamide-based glycogen synthase kinase-3β (GSK-3β) inhibitors: 3D-QSAR, molecular docking, molecular dynamics simulation and ADMET studies. [J].New Journal of Chemistry.2025,49(15):6151-6163.
[8]YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning,Taigang Liang*, Mingzhu Zhao*, Jian Zhang*.Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase.[J].RSC Medicinal Chemistry.2025;16(2):826-834.
[9]Haidi Li, Yuankui Jin, Minfan Pei, Linyan Zhang, Lianjun Wang, Yuxin Yang, Peng Xiang,Taigang Liang*. TAG‐Assisted Liquid‐Phase Synthesis and Structure Activity Relationship of Macolacin‐Based Side‐to‐Tail Cyclopeptides Antibiotic. [J]. Chinese Journal of Chemistry. 2024.
[10]Haidi Li, Lianjun Wang, Linyan Zhang, Yuxin Yang, Yuankui Jin, Jian Zhang,Taigang Liang*. Scalable preparation of green C-terminal amidation peptide-synthesis TAGs and the optimized TAG-assisted liquid-phase synthesis of eptifibatide.[J]. Sustainable Chemistry and Pharmacy.2024, 41: 101684.
[11]Chungiang Wang, Yuzhu Fan, Minfan Pei, Chaoqun Yan,Taigang Liang*, 3D and 2D-QSAR Studies on Natural Flavonoids for Nitric Oxide Production Inhibitory Activity.[J].Letters in Drug Design & Discovery.2024.
[12]Yidan Sun, Chaoqun Yan, Tingting Liang, Wen Li, Minfan Pei, Linyan Zhang, Qingshan Li,Taigang Liang*. Comparative study on interactions of phillyrin and phillygenol with lysozyme: Spectroscopy, differential scanning calorimetry and molecular modeling approaches.[J]. Journal of Molecular Liquids.2024: 124571.
[13]梁婷婷,张璐,闫超群,梁泰刚*.N-取代马来酰亚胺类hMGL抑制剂的3D-QSAR、分子对接和分子动力学研究. [J].化学通报. 2024.
[14] Haidi Li*, Yuankui Jin, Lianjun Wang, Linyan Zhang, Tianyu Liu, Yu Liu,Taigang Liang*. One-pot and sustainable liquid-phase peptide extension for synthesis of C-terminal amidation peptides aided by small molecular tags.[J]. Organic Chemistry Frontiers.2023,10(24): 6158-6165.
[15]张春雨,向楠,李树颖,陈晓光,金晶,梁泰刚*.S1P1调节剂IMMHO02对自身免疫性肝炎的治疗作用及机制研究. [J].药学学报. 2023,58(12).
[16]王春强,云阳,梁马丹,梁泰刚*.雷公藤甲素诱导自噬促进人肾小管上皮HK-2细胞凋亡. [J].中国药理学通报. 2023,(11):2133-2140.
[17]段治宇,王效蕊,梁婷婷,李青山,梁泰刚*.青藤碱对有机锡损伤肝HL02细胞的保护作用及其机制.[J].中国药理学通报.2022,28(10):1535-1541.
[18] Wen Li, Yuzhu Fan, Chaoqun Yan, YanDu, Tingting Liang, Chunqiang Wang, Liwei Wang, Lingling Han, Qingshan Li*,Taigang Liang*. Triptolide and Methotrexate Binding Competitively to Bovine Serum Albumin: A Study of Spectroscopic Experiments, Molecular Docking, and Molecular Dynamic Simulation.[J]. Journal of Molecular Liquids.2022,367:120300.
[19] Liwei Wang, Zhiyu Duan, Madan Liang, Chunqiang Wang*, Tingting Liang, Liqian Sun, Chaoqun Yan, Qingshan Li*,Taigang Liang*. A pivotal role of selective autophagy in mitochondrial quality control: Implications for zinc oxide nanoparticles induced neurotoxicity.[J]. Chemico-Biological Interactions.2022,363:110003.
[20] Zhiyu Duan, Madan Liang, Congcong Yang, Chaoqun Yan, Liwei Wang, Jiaqi Song, Lingling Han, Yuzhu Fan, Wen Li,Taigang Liang*, Qingshan Li*.Selenium nanoparticles coupling with Astragalus Polysaccharides exert their cytotoxicities in MCF-7 cells by inhibiting autophagy and promoting apoptosis.[J]. Journal of Trace Elements in Medicine and Biology.2022,73:127006.
[21] Lingling Han, Jiaqi Song, Chaoqun Yan, Chunqiang Wang, Liwei Wang, Wen Li, Yan Du, Qingshan Li*,Taigang Liang*. Inhibitory activity and mechanism of calycosin and calycosin-7-O-β-D-glucoside onα-glucosidase: Spectroscopic and molecular docking analyses. [J]. Process Biochemistry. 2022,118:227-235.
[22]Chaoqun Yan, Xiaoyan Zhang, Junqiu Miao, Hongxia Yuan, Enli Liu,Taigang Liang*, Qingshan Li*. Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway and Protect EA. hy926 Cells against Oxidative Stress-Induced Injuries. [J]. Oxidative Medicine and Cellular Longevity.2020,2020:1-15.
[23]Dongxiao Cui, Jun Ma, Tingting Liang, Liqian Sun, Liqiang Meng,Taigang Liang*,Qingshan Li. Selenium nanoparticles fabricated in laminarin polysaccharides solutions exert their cytotoxicities in HepG2 cells by inhibiting autophagy and promoting apoptosis. [J]. International Journal of Biological Macromolecules.2019,137:829-835.
[24]Liwei Wang, Tingting Liang, Jun Ma, Liqian Sun, Congcong Yang, Liqiang Meng,Taigang Liang*, Qingshan Li*. Effects of nanoparticle size on the interaction between zinc oxide nanoparticles and bovine serum albumin. [J]. Journal of Biomolecular Structure and Dynamics.2019,37(1):1-8.
[25]Dongxiao Cui, Tingting Liang, Liqian Sun, Liqiang Meng, Congcong Yang, Liwei Wang,Taigang Liang*,Qingshan Li*. Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis. [J]. Pharmaceutical Biology.2018,56(1):528-534.
[26]Dongxiao Cui, Chaoqun Yan, Junqiu Miao, Xiaoyan Zhang, Jingrun Chen, Liqian Sun, Liqiang Meng,Taigang Liang*, Qingshan Li*. Synthesis, characterization and antitumor properties of selenium nanoparticles coupling with ferulic acid. [J]. Materials Science and Engineering: C.2018,90:104-112.
[27]Liqiang Meng, Liqian Sun, Chaoqun Yan, Dongxiao Cui, Jingrun Chen,Taigang Liang*, Qingshan Li*. 3D QSAR Studies of Tricyclic Compounds as Porcupine Inhibitors for Wnt Pathway Inhibitory Activity. [J]. Letters in Drug Design & Discovery.2018,15(7):721-732.
[28]Liqian Sun,Taigang Liang*,Qingshan Li*. 3D-QSAR Studies on 4-([1,2,4]Triazolo[1,5-α]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole Analogues as Potent Inhibitors of Transforming Growth Factor-β Type I Receptor Kinase. [J]. Chinese Journal of Structural Chemistry.2018,37(4):563-572.
[29]Jingrun Chen, Junjie Liu, Dongxiao Cui, Chaoqun Yan, Liqiang Meng, Liqian Sun, Shurong Ban, Rui Ge,Taigang Liang*,Qingshan Li*. Synthesis and cytotoxic activities of novel 4-methoxy-substituted and 5-methyl-substituted (3′S,4′S)-(-)-cis-khellactone derivatives that induce apoptosis via the intrinsic pathway. [J]. Drug Design, Development and Therapy.2017,11:1891-1904.
[30]Xiaorui Wang, Junqiu Miao, Chaoqun Yan, Rui Ge,Taigang Liang*, Enli Liu, Qingshan Li*. Chitosan attenuates dibutyltin-induced apoptosis in PC12 cells through inhibition of the mitochondria-dependent pathway. [J]. Carbohydrate Polymers.2016,151:996-1005.
[31]Junqiu Miao, Suhai He, Xiushan Dong,Taigang Liang*, Qingshan Li. 3D-QSAR Studies on 3-substituted N-benzhydryl-nortropane Analogs as Nociception Receptor Agonists. [J]. Chinese Journal of Structural Chemistry.2016,35(9):1319-1327.
[32]Chaoqun Yan, Jiali Zhang,Taigang Liang*, Qingshan Li*. Diorganotin(IV) complexes with 4-nitro-N-phthaloyl-glycine: Synthesis, characterization, antitumor activity and DNA-binding studies. [J]. Biomedicine & Pharmacotherapy.2015,71:119-127.
[33]Taigang Liang, Chaoqun Yan, Li Yang, Mengnan Hu, Shurong Ban, Qingshan Li. 3D-QSAR studies of 8-substituted chromen-4-one-2-carboxylic acid derivatives as potent agonists for the Orphan G Protein-Coupled Receptor 35. [J]. Medicinal Chemistry Research.2014,23(10):6641-6656.
[34]Enli Liu, Xue Du, Rui Ge,Taigang Liang*,Qiao Niu, Qingshan Li*. Comparative toxicity and apoptosis induced by diorganotins in rat pheochromocytoma (PC12) cells. [J]. Food and Chemical Toxicology.2013,60:302-308.
[35]Taigang Liang, Luhui Ren, Qingshan Li*. 3D-QSAR studies of tetraoxanes derivatives as antimalarial agents using CoMFA and CoMSIA approaches. [J]. Bulletin of the Korean Chemical Society.2013,34(6):1823-1828.
