郭丽霞
山西医科大学药学院药物化学教研室，讲师，理学博士
E-mail:guolxia@sxmu.edu.cn
教育经历
2015年9月—2020年7月 山西大学，博士（硕博连读）
2011年9月—2015年7月 太原师范学院，学士
工作经历
2022年3月—至今 在站博士后，山西医科大学第三临床医学院
2020年9月—至今 山西医科大学，药学院，讲师
荣誉获奖
山西省自然科学二等奖，山西省科技厅，2022
教学情况
主要承担承担了《有机化学》、《化学生物学》《药学进展》的教学，以及有机化学和药物化学的实验准备工作。
研究领域
聚焦于有机功能分子的设计、合成，以及纳米自组装体的构建，致力于其在疾病诊断、抗菌领域的应用。在有机功能分子设计合成方面，构建具有特定光学、电学或化学活性的有机分子，利用其对生物标志物的特异性识别能力，实现疾病的早期精准诊断；设计合成具有抗菌活性的有机分子及纳米自组装体，探索其对耐药菌的作用机制，为解决抗生素耐药问题提供新思路。
代表性科研、教改项目
1、中国博士后科学基金面上资助，中国博士后科学基金会，8万元，在研，主持。
2、山西省博士启动基金，5万，在研，主持。
3、山西省自然科学基金青年项目，山西省科技厅，5万元，结题，主持。
代表性论著
1、发表论文：
(1) Lixia Guo, Xiaowan Li, Run Zhang, Yixuan Hou, Bolong Ma, Zheng Li, Jiye Lv, Bin Wang, Sufang Ma, Lihong Li, Lili Yan, Boye Zhang, Wen Liu, Kahleong Lim, Haipeng Diao*, Shaowei Wang*, Chengwu Zhang*. In situ dual-activated NIRF/PA carrier-free nanoprobe for diagnosis and treatment of Parkinson’s disease. Biosensors and Bioelectronics, 2025, 282, 117473.
(2) Lixia Guo, Xiaowan Li, Shangyu Xie, Baizhi Su, Na Yang, Bin Wang, Sufang Ma, Lihong Li, Lili Yan, Boye Zhang, Wen Liu, Kahleong Lim, Yang Liu*, Haipeng Diao*, Chengwu Zhang*. Double-locked probe for NIRF/PA imaging mitochondrial H2O2 and viscosity in Parkinson’s disease. Sensors & Actuators: B. Chemical, 2025, 205, 111370.
(3) Lixia Guo, Yafei Tian, Liang Zhou, Shiyue Kang, Chengwu Zhang, Wen Liu, Haipeng Diao, Liheng Feng. Tailored phototherapy agent by infection site in situ activated against methicillin-resistant S. aureus. Advanced Healthcare Materials, 2024, 2400593.
(4) Lixia Guo, Jiahuan Liu, Xiaowan Li, Yinyu Ma, Shiyue Kang, Yafei Tian, Bin Wang, Sufang Ma, Lihong Li, Lili Yan, Chengwu Zhang, Wen Liu, Haipeng Diao*, Shurong Ban*, Ruiping Zhang*, Liheng Feng*. An activatable NIR fluorescent/photoacoustic probe for rapid identification of β-lactam-resistant bacteria，Microchemical Journal, 2024, 205, 111368.
(5) Jiahuan Liu, Xiaowan Li, Shangyu Xie, Ruirui Ma, Hongfei Wang, Shurong Ban*, Chengwu Zhang*, Lixia Guo*. Fabricating a PDA-NOate@CuS coated NIR-activatable titanium implant to realize simultaneous antiinfection and osseointegration. New Journal of Chemistry, 2024, 48, 11465-11475.
(6) Lixia Guo, Xueyun Zhang, Danning Wen, Lei Ding, Yan Niu, Lihong Li, Wen Liu, Haipeng Diao*, Liheng Feng*. A Novel Two-channel Ratio Fluorescent Probe for Monitoring Intracellular pH Fluctuations. Sensors and Actuators B: Chemical, 2022, 360, 131656.
(7) Lixia Guo, Haoping Wang, Yunxia Wang*, Feng Liu*, Liheng Feng*. Organic Polymer Nanoparticles with Primary Ammonium Salt as Potent Antibacterial Nanomaterials. ACS Applied Materials & Interfaces, 2020, 12, 21254−21262.
(8) Lixia Guo, Haoping Wang, Yunxia Wang*, Liheng Feng*. Tailor-Made Polymer Nano-Assembly with Switchable Function and Amplified Anti-Tumor Therapy. Advanced Healthcare Materials, 2019, 1901492.
(9) Lixia Guo, Haoping Wang, Yunxia Wang*, Liheng Feng*. Facile core-shell nanoparticles with controllable antibacterial activity assembled by chemical and biological molecules. Biomaterials Science, 2019, 7, 5528-5534.
(10) Lixia Guo, Xiaoju Wang, Liheng Feng*. Synthesis, photophysical and electrochemical properties of a blue emitter with binaphthalene and carbazole units. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 201, 376-381.
(11) Liheng Feng*, Lixia Guo, Xiaoju Wang. Preparation, properties and applications in cell imaging and ions detection of conjugated polymer nanoparticles with alcoxyl bonding fluorene core. Biosensors and Bioelectronics, 2017, 87, 514-521.
(12) Xiaoju Wang#, Lixia Guo#, Liheng Feng*. A multi stimuli responsive material with rhodamine B and carbazole groups. New Journal of Chemistry, 2019, 43, 4181-4187.
(13) Tao Qin#, Lixia Guo#, Haipeng Diao*, Liheng Feng*. Facile Antibacterial Materials with Turbine-like Structure for P. aeruginosa Infected Scald Wounds Healing. Biomaterials Science, 2021, 9, 3830.
2、授权专利
(1) 郭丽霞，刘文，田亚飞，李锦瑶，任国栋，马素芳，张承武，李丽红，刁海鹏，王浩江，王斌，闫丽丽. 一种检测耐药菌中β-内酰胺酶的近红外荧光探针的制备, 专利号：ZL202211255743.4，授权日：2023-08-29。
(2) 郭丽霞，冯丽恒. 具有可视化诊断和治疗感染伤口的温敏水凝胶及制备方法，专利号：ZL201911364220.1，授权日：2021.3.30。
(3) 冯丽恒，郭丽霞. 一种蓝光发光材料及其制备方法. 国内发明专利，专利号：ZL201610200923.0，授权日：2017.11.3。
(4) 冯丽恒，郭丽霞. 一种环状聚合物及其制备方法和应用. 国内发明专利，专利号：ZL201810189654.1，授权日：2020.2.14。
