任鹏璇
药物化学教研室 讲师 博士
E-mail: rpxsmkx@163.com
个人主页或网站：https://www.researchgate.net/profile/Pengxuan-Ren
教育经历
2019年9月—2024年7月 上海科技大学，硕博连读
2014年9月—2018年7月 中国药科大学，学士
工作经历
2024年8月—至今 山西医科大学 讲师
研究领域
计算生物学、人工智能、药物设计。致力于针对关键药物靶标，应用计算机辅助药物设计方法和人工智能算法发现和设计药物。
代表性科研、教改项目
1、科技部, 国家重点研发计划, 2020YFA0509700, 植物隐花色素蛋白机器光反应的分子动态机制研究,2020-11 至 2025-10, 90万元, 参与。
2、上海市科委, 青年科技启明星, 20QA1406400, 基于分子片段的蛋白质-蛋白质作用调控剂的设计方法,2020-06 至 2023-05, 40万元, 参与。
代表性论著
1、Pengxuan Ren; Weijuan Shang; Wanchao Yin; Huan Ge; Lin Wang; Xianglei Zhang; Bingqian Li; Honglin Li; Yechun Xu; Eric H Xu; Hualiang Jiang; Lili Zhu; Leike Zhang; Fang Bai ; A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors, Acta Pharmacologica Sinica, 2022, 43(2): 483-493.
2、Pengxuan Ren; Changyue Yu; Ruxue Zhang; Tianqing Nie; Qiaoyu Hu; Hui Li; Xianglei Zhang; Xueyuan Zhang; Shiwei Li; Lu Liu; Wenhao Dai; Jian Li; Yechun Xu; Haixia Su; Leike Zhang; Hong Liu; Fang Bai ; Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2, European Journal of Medicinal Chemistry, 2023, 249: 115129.
3、Pengxuan Ren; Hui Li; Tianqing Nie; Xiaoqin Jian; Changyue Yu; Jian Li; Haixia Su; Xianglei Zhang; Shiwei Li; Xin Yang; Chao Peng; Yue Yin; Leike Zhang; Yechun Xu; Hong Liu; Fang Bai ; Discovery and mechanism study of SARS-CoV-2 3C-Like protease inhibitors with a new reactive group, Journal of Medicinal Chemistry, 2023, 66(17): 12266-12283.
4、Pengxuan Ren; Shiwei Li; Shihang Wang; Xianglei Zhang; Fang Bai ; Computer-aided prediction of the interactions of viral proteases with antiviral drugs: antiviral potential of broad-spectrum drugs, Molecules, 2023, 29(1): 225-225.
5、Zongquan Li; Pengxuan Ren; Hao yang; Jie Zheng; Fang Bai ; TEFDTA: a transformer encoder and fingerprint representation combined prediction method for bonded and non-bonded drug-target affinities, Bioinformatics, 2023, 40(1): btad778.
6、Sanjeev Kiran Gotru; Elmina Mammadova-Bach; Georgios Sogkas; Michael K. Schuhmann; Karen Schmitt; Peter Kraft; Sabine Herterich; Medina Mamtimin; Akif Pinarci; Sarah Beck; Simon Stritt; Han Chao; Pengxuan Ren; Jean-Noël Freund; Christian Klemann; Felix C. Ringshausen; Johan W.M. Heemskerk; Alexander Dietrich; Bernhard Nieswandt; Guido Stoll; Thomas Gudermann; Attila Braun ; MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice, Arteriosclerosis, Thrombosis, and Vascular Biology, 2023, 48(8): 1494-1509.
