张华屏
博士
教授
研究方向:金雀异黄酮预防衰老的机制研究
邮箱: zhanghuaping@sxmu.edu.cn
联系地址:山西省太原市新建南路56号
教育经历:
2001/09-2004/07,四川大学,病原生物学,获博士学位
1998/09-2001/07,山西医科大学,病原生物学专业,获硕士学位
1992/09-1997/07,山西医科大学,临床医学,获学士学位
工作经历:
2017/12-至今,山西医科大学,转化医学研究中心, 教授
2006/08-2017/11,山西医科大学,转化医学研究中心, 副教授
2001/07-2006/07,山西医科大学,医学实验中心,讲师
1. 山西省教育厅青年科技研究基金, 2007021046, 植物雌激素genistein诱导表达eNOS作用机制的研究,2007/01-2009/12,5万元。
2. 山西省教育厅面上自然基金项目, 201801D121317, 金雀异黄酮通过调节miR-34a和SIRT1抑制血管内皮细胞老化的研究,2018/12-2020/12,5万元。

实验技术基础(硕士研究生)
高级实验技术(博士研究生)
1.Huaping Zhang, Xuefen Pang, Haixia Yu, Hui Zhou. Genistein suppresses ox-LDL-elicited oxidative stress and senescence in HUVECs through the SIRT1-p66shc-Foxo3a pathwaysJ Biochem Mol Toxicol. 2022 Jan; 36(1): e22939. doi: 10.1002/jbt.22939.
2.Huaping Zhang, Xiaorong Yang, Xuefen Pang, Zhenxiang Zhao, Haixia Yu, Hui Zhou. Genistein protects against ox-LDL-induced senescence through enhancing SIRT1/LKB1/AMPK-mediated autophagy flux in HUVECs. Molecular and Cellular Biochemistry. 2019; 455: 127–134
3.Zhang H, Zhao Z, Pang X, Yang J, Yu H, Zhang Y, Zhou H, Zhao J. MiR-34a/sirtuin-1/foxo3a is involved in genistein protecting against ox-LDL-induced oxidative damage in HUVECs. Toxicol Lett. 2017; 277:115-122.
4.Zhang H, Zhao Z, Pang X, Yang J, Yu H, Zhang Y, Zhou H, Zhao J. Genistein Protects Against Ox-LDL-Induced Inflammation Through MicroRNA-155/SOCS1-Mediated Repression of NF-ĸB Signaling Pathway in HUVECs. Inflammation. 2017; 40(4):1450-1459.
5.Zhang HP, Zhao JH, Yu HX, Guo DX. Genistein ameliorated endothelial nitric oxidase synthase uncoupling by stimulating sirtuin-1 pathway in ox-LDL-injured HUVECs. Environ Toxicol Pharmacol. 2016; 42:118-124.
6.Huaping Zhang, Fengli Zheng, Jiahui Zhao, Dongxing Guo, Xiaolong Chen. Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1. Archives of Medical Research. 2013; 44(1):13-20.
7.Huaping Zhang, Dongxing Guo, Lianyun Wang, Yangxing Zhao, Yu Cheng, Zhongdong Qiao. Effect of nicotine on Oct-4 and Rex-1 expression in mouse embryonic stem cells. Reproductive Toxicology. 2005, 19(4): 473-478.
8.H  Zhang,Z  Zhu,L  Liu,D  Guo, T  Jiang, L Wang,Z qiao.Upregulation of Fas and FasL expression in testosterone-induced apoptosis of macrophages. Methods Find Exp Clin Pharmacol. 2003, 25(10): 779-784.
9.Huaping Zhang,Jiahui Zhao,Peigang Wang,Zhongdong qiao. Effect of testosterone on leishmania donovani infection of macrophages. Parasitol Res. 2001, 87: 674-676.