代表性成果 （论文/专利/专著等） |
1. Li Zhang#*，Xiaona Zhang#，Yurong Liu#，Kaixin Wei#，Huijing Ma，Li Xia，Rui Cao，Yuqing Sun，Ronghua Zheng，Xiuwei Wang*，Bingmei Chang*. Ethionine‐induced S‐adenosylmethionine deficiency suppressed H3K27me3 and cell differentiation during neural tube development in mice. J Cell Physiol. 2025 Jan;240(1):e31452. 2. Li Zhang#, Dandan Li#, Yurong Liu, Xiaona Zhang, Kaixin Wei, Xiaorong Zhao, Huijing Ma, Bo Niu, Rui Cao*, Xiuwei Wang*. Cycloleucine induces neural tube defects by reducing Pax3 expression and impairing the balance of proliferation and apoptosis in early neurulation. Neurochemistry International.2024.105861. Epub 2024 Sep 20. 3.Wenhao Shao#, Huaxing Ding#, Yan Wang, Zhiyong Shi, Hezhao Zhang, Fanxiu Meng, Qingyao Chang, Haojiang Duan, Kairui Lu, Li Zhang*, Jun Xu*.Key genes and immune pathways in T-cell mediated rejection postliver transplantation identified via integrated RNA-seq and machine learning.Scientific Reports 2024 Oct 16;14(1):24315. 4.Rui Cao, Yurong Liu, KaixinWei, Ning , Yuxiang , RuifangAo, Weiwei Pan, XiangWang, XiuweiWang*, Li Zhang* & Jun Xie*. Genes related to neural tube defects and glioblastoma.Scientific Reports 2025 Jan 30;15(1):3777. 5.Xiuwei Wang, Kaixin Wei, Min Wang**, Li Zhang*. Identification of potential key ferroptosis and autophagy-related genes in myelomeningocele through bioinformatics analysis. Heliyon 2024 Apr 30;10(8):e29654. 6.Haojiang Duan, Qingyao Chang, Huaxing Ding, Wenhao Shao, Yan Wang, Kairui Lu, Li Zhang*, Jun Xu*. GBP1 promotes acute rejection after liver transplantation by inducing Kupffer cells pyroptosis. Biochim Biophys Acta Mol Basis Dis. 2024 Dec 26:167644. 7.Yuxuan Zhang，Qingjuan Li, Yuhu Niu, Kaixin Wei, Xiuwei Wang, Bo Niu，Li Zhang*. Research progress on aging mechanism and drugs and the role of stem cells in anti-aging process. Experimental Gerontology. 2023 Aug;179. 8.Rui Cao, Jun Xie*, Li Zhang*. Abnormal methylation caused by folic acid deficiency in neural tube defects.Open Life Sciences 2022; 17: 1679-1688. 9.Li Zhang, Rui Cao, Dandan Li, Yuqing Sun, Juan Zhang, Xiuwei Wang, Ajab Khan, Zhizhen Liu, Bo Niu*, Jun Xu* and Jun Xie*. Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway. Epigenetics & Chromatin. 2021 Dec 4;14(1):52. 10.Zhang L, Dong Y, Wang W, Zhao T, Huang T, Khan A, Wang L, Liu Z, Xie J and Niu B. Ethionine Suppresses Mitochondria Autophagy and Induces Apoptosis via Activation of Reactive Oxygen Species in Neural Tube Defects. Front Neurol. 2020 Apr 7;11:242. 11.Li Zhang, Dandan Li, Juan Zhang, Ping Yan, Ajab Khan, Xueqin Liu, Lei Wang, Zhizhen Liu, Jianbing Mu, Jun Xu, Bo Niu*, Jun Xie*. Excessive apoptosis and ROS induced by ethionine affects neural cells viability and differentiation[J]. Acta Biochimica et Biophysica Sinica 2020 Oct 19;52(10). 12.Sansan Jia#, Li Zhang#, Kaili Zhang, Lei Wang, Ajab Khan, Juan Zhang, Yuqing Sun, Yufei Wang, Meiyan Song, Yi Lyu, Meining Li, Xin Lu, Bo Niu, Zhizhen Liu*, and Jun Xie*. Nkx2.1 downregulation is involved in brain abnormality induced by excess retinoic acid [J]. Acta Biochim Biophys Sin. 2020 Jun 20;52(6):683-690. 13.张丽，张钰璇，卫凯鑫，刘雨榕，张晓娜，孙雨晴，马惠静，曹睿，郑荣华，王秀伟，于保锋. 乙硫氨酸通过 MAT2A/β-连环蛋白/ZEB1/EMT通路调控小鼠神经管畸形的机制.中华围产医学杂志 2025, Vol. 28(03):1-8. 14.曹睿，卫凯鑫，张晓娜，刘雨榕，张丽*. 视黄酸诱导的小鼠神经管畸形基因表达趋势分析.上海交通大学学报 （医学版），2024, Vol. 44 (07)：859-870. 15.张丽，张钰璇，王秀伟，李建婷，赵娟，孙雨晴，刘娟娟，张丽慧，曹睿，解军. 乙硫氨酸对神经管畸形胎鼠脑组织Fos和Cyp2e1基因表达的影响.中华实用诊断与治疗杂志. 2023,37(04),325-331. |
