代表性成果 （论文/专利/专著等） |
代表性论文： 1. Tang J, Zhang W, Xu J, Sun L, Dang Y, Li H, Yu L, Su J, Xue T, Guo R, Xie J*, Wang L*. Solid-state fermentation of distillers grains with Aspergillus pachycristatus for echinocandin B biosynthesis. Bioresource Technol. 2025;425:132334 2. Wang L#, Dong C#, Zhang W, Ma X, Rou W, Yang K, Cui T, Qi S, Yang L, Xie J, Yu G, Wang L, Chen X, Liu Z. Developing an enhanced chimeric permuted intron-exon system for circular RNA therapeutics. Theranostics. 2024;14(15):5869-5882. 3. Wang L#, Liu J#, Tang J, Dang Y, Sun L, Liu B, Li H, He X, Shuai Q, Peng Z, Huang T, Sun Y, Feng Y, Xie J. Development of a quinic acid-induced CRISPR/Cas9 genome editing system and its application for the activation of ilicicolin H biosynthesis in Trichoderma reesei. Int J Biol Macromol. 2024;279(Pt 4):135339. 4. Ma C, Liu J, Tang J, Sun Y, Jiang X, Zhang T, Feng Y, Liu Q, Wang L*. Current genetic strategies to investigate gene functions in Trichoderma reesei. Microb Cell Fact, 2023, 22(1): 97. 5. Wang L, Liu J, Li X, Lyu X, Liu Z, Zhao H, Jiao X, Zhang W, Xie J, Liu W. A histone H3K9 methyltransferase Dim5 mediates repression of sorbicillinoid biosynthesis in Trichoderma reesei. Microb Biotechnol, 2022, 15(10): 2533-2546. 6. Wang L#, Zhang W#, Cao Y, Zheng F, Zhao G, Lv X, Meng X, Liu W. Interdependent recruitment of CYC8/TUP1 and the transcriptional activator XYR1 at target promoters is required for induced cellulase gene expression in Trichoderma reesei. PLoS Genet, 2021, 17(2): e1009351. 7. Wang L, Yang R, Cao Y, Zheng F, Meng X, Zhong Y, Chen G, Zhang W, Liu W. CLP1, a novel plant homeo domain protein, participates in regulating cellulase gene expression in the filamentous fungus Trichoderma reesei. Front Microbiol, 2019, 10: 1700. 8. Wang L, Lv X, Cao Y, Zheng F, Meng X, Shen Y, Chen G, Liu W, Zhang W. A novel transcriptional regulator RXE1 modulates the essential transactivator XYR1 and cellulase gene expression in Trichoderma reesei. Appl Microbiol Biotechnol, 2019, 103(11): 4511-4523. 9. Wang L, Zheng F, Zhang W, Zhong Y, Chen G, Meng X, Liu W. A copper-controlled RNA interference system for reversible silencing of target genes in Trichoderma reesei. Biotechnol Biofuels, 2018, 11: 33. 专著： Wang L, Zhang W, Meng X, Liu W. The copper-controlled RNA interference system in Trichoderma reesei. Methods Mol Biol, 2021, 2234: 99-111. 授权专利： 1. 一种基于I型内含子核酶体外制备环状RNA的系统及其应用（202410221889.X）；发明专利，中国 2. 一种利用嵌合PIE系统体外制备环状RNA的方法与应用（202410088465.0）；发明专利，中国 3. 一株高产sorbicillinoids的里氏木霉工程菌及其构建方法与应用（202011452922.8）；发明专利，中国 |
