药理学您现在的位置是: 学院首页 >> 人才建设 >>

范彦英
2020-06-16 11:56:40       来源:

基础医学院研究生导师个人信息

姓    名

范彦英

性   别

出 生 年

1983

系/教研室

药理教研室

职    称

教授

职    务

副主任

导师类型

博导

最高学历/学位/毕业院校

浙江大学

E-mail

fyanying6@hotmail.com

学科专业

药理学

研究方向

神经药理

工作单位

山西医科大学基础医学院

人才称号/学术兼职

山西省“三晋英才”青年优秀人才、中国卒中学会青年工作委员会常务委员、中国卒中学会新药研发与评价分会常务委员、Neurochemistry International和Journal of Integrative Neuroscience杂志编委

学习工作经历

2002.9-2006.6:浙江大学竺可桢荣誉学院理科班,生物科学专业,本科/学士

2006.9-2011.6:浙江大学医学院,药理学专业(硕博连读),博士研究生/博士

2011.7-2014.12:山西医科大学基础医学院药理教研室,任讲师

2015.1-2020.12:山西医科大学基础医学院药理教研室,任副教授,硕导

2020.12至今: 山西医科大学基础医学院药理教研室副主任,博导

2022/12-至今:山西医科大学基础医学药理教研室,任教授,副主任,博导

主持的科研

/教学项目

(1)      山西省科技创新人才团队(202304051001039),基于新靶点的脑卒中靶向治疗药物研发,2023/08-2026/08,   100万元,在研,主持

(2)        国家自然科学基金面上项目,81872854,延迟性慢性酸后处理对脑缺血后神经修复的促进作用及机制,2019/01-2022/12,57万元,结题,主持

(3)        山西省“四个一批”科技兴医创新计划重点科研项目(2023XM035),TDAG8激动剂促脑缺血后神经修复的作用研究及其仿生脑靶向纳米递药系统的构建和评价,2023/09-2025/09,15万元,在研,主持

(4)        山西省基础研究计划面上项目(202303021211118),神经元GPR65受体激活对脑缺血后神经修复的促进作用及机制研究,2024/01-2026/12,10万元,在研,主持

(5)        国家自然科学基金青年项目,81202520,酸后处理对缺血性脑卒中的保护作用及与酸敏感通道ASIC1a的相关性研究,2013/01-2015/12,23万元,已结题,主持

(6)        高等学校博士学科点专项科研基金资助项目新教师联合类,20121417120002,酸后处理对脑缺血再灌注损伤的保护作用及其机制研究,2013/01-2015/12,4万元,已结题,主持

(7)        2018年山西省高等学校科技创新项目,201802058,延迟性慢性酸后处理对脑缺血后神经修复的促进作用及与TDAG8的相关性,2018/07-2020/12,1万元,结题,主持

(8)        山西省青年科技基金,2014021038-1,脑缺血再灌后酸化处理的神经保护作用及其与mPTP的关系,2014/01-2017/12,3万元,结题,主持

(9)        细胞生理学教育部重点实验室(山西医科大学)2019年开放基金重点项目(负责人,KLMEC/SXMU-201901,5万元),TDAG8在脑缺血后神经修复中的作用及机制研究。2020/01-2021/12,5万元,结题,主持

代表性成果

(论文/专利/专著等)

(1)        Chen R, Zhang MQ, Miao YL, Zhang SH, Cheng Y,   Wang SS, Yin J, Yang CH, Zhang HF, Tang L, Li Y*, Zhang Y*, Fan YY(范彦英)*. Targeting Neuronal   GPR65 With Delayed BTB09089 Treatment Improves Neurorehabilitation Following   Ischemic Stroke. Stroke. 2024 Aug;55(8):2151-2162. (IF:7.9)

(2)        Zhang SH, Yin J, Jing LJ, Cheng Y, Miao YL,   Fan B, Zhang HF, Yang CH, Wang SS, Li Y*, Jiao XY*, Fan YY(范彦英)*. Targeting astrocytic   TDAG8 with delayed CO2 postconditioning improves functional outcomes after   controlled cortical impact injury in mice. Exp Neurol. 2024 Oct;380:114892. (IF:4.6)

(3)        Huo J, Feng L, Cheng Y, Miao YL, Liu W, Hou   MM, Zhang HF, Yang CH, Li Y, Zhang MS, Fan YY. Delayed simvastatin treatment   improves neurological recovery after cryogenic traumatic brain injury through   downregulation of ELOVL1 by inhibiting mTOR signaling. Brain Res Bull. 2024   Sep 5:111072. (IF: 3.5)

(4)        Xu X, Fan Y, Yang X, Liu Y*, Wang Y, Zhang J,   Hou X, Fan Y(范彦英)*,   Zhang M*. Anji white tea relaxes precontracted arteries, represses   voltage-gated Ca channels and voltage-gated K channels in the arterial smooth   muscle cells: Comparison with green tea main component (-)-epigallocatechin   gallate. J Ethnopharmacol. 2024;Jun 28:328:117855. DOI:10.1016/j.jep.2024.117855   (IF: 5.4)

(5)        Fan YY(范彦英)#*, Li Y#, Tian XY#, Wang YJ#, Huo J, Guo BL, Chen R, Yang CH, Li Y,   Zhang HF, Niu BL*, Zhang MS*. Delayed Chronic Acidic Postconditioning   Improves Poststroke Motor Functional Recovery and Brain Tissue Repair by   Activating Proton-Sensing TDAG8. Translational Stroke Research. 2023; DOI:   10.1007/s12975-023-01143-7 (IF: 6.9)

(6)        Li Y, Chen R, Shen GP, Yin J, Li Y, Zhao J,   Nan F, Zhang SH, Zhang HF, Yang CH, Wu MN*, Fan YY(范彦英)*. Delayed CO2 postconditioning promotes neurological recovery   after cryogenic traumatic brain injury by downregulating IRF7 expression. CNS   Neurosci Ther. 2023;29(11):3378-3390. doi: 10.1111/cns.14268 (IF:5.5)

(7)        Yin J, Tuo CM, Yu KY, Hu XH, Fan YY(范彦英)*, Wu MN*, Diurnal Characteristics of the Orexin System Genes and   Its Effects on Pathology at Early Stage in 3xTg-AD Mice. Neuromolecular Med,   2023 Oct 16, DOI:10.1007/s12017-023-08767-w   (IF:3.5)

(8)        Yang CH*, Qiu HQ, Wang C, Tang YT, Zhang CR,   Fan YY(范彦英)*,   Jiao XY*. Levosimendan Relaxes Thoracic Aortic Smooth Muscle in Mice by   Inhibiting PKC and Activating Inwardly Rectifying Potassium Channels. J   Cardiovasc Pharmacol. 2024 May 1;83(5):474-481(IF: 2.6)

(9)      Zhang J, Du Y, Zhang Y, Xu Y, Fan Y(范彦英)* , Li Y*.1H-NMR Based Metabolomics Technology Identifies   Potential Serum Biomarkers of Colorectal Cancer Lung Metastasis in a Mouse   Model. Cancer Manag Res. 2022;14 (IF:3.602)

(10)     Guo P#,  Liu Y#,  Xu X,  Ma G,  Hou X,  Fan YY(范彦英)*,  Zhang M*.Coronary   hypercontractility to acidosis owes to the greater activity of TMEM16A/ANO1   in the arterial smooth muscle cells. Biomed Pharmacother. 2021;139 (IF: 7.419)

(11)   Fan YY(范彦英)#*, Huo J#. A1/A2   astrocytes in central nervous system injuries and diseases: Angels or devils?   Neurochemistry International. 2021;148:105080   (IF:4.297)

(12)   Fan Y(范彦英)#*,Wang YJ#, Guo J#, Wu   MN, Zhang MS, Niu BL, Li Y, Zhao J, YangCH,Li   Y, Chen M, Jiao XY*. Delayed   metformin treatment improves functional recovery following traumatic brain   injury via central AMPK-dependent brain tissue repair. Brain   Res. Bull. 2020; 26;164 (IF: 4.077)

(13)     Niu B*, Li M, Jia J, Zhang C, Fan YY*(范彦英),   Li W. Hydrophobin-enhanced stability, dispersions   and release of curcumin nanoparticles in water. J   Biomater Sci Polym Ed. 2020   Oct;3114(14) (IF:2.69)

(14)     Niu B, Guo J , Guo X, Sun X, Rao C, Liu C,   Zhang J, Zhang C, Fan YY*(范彦英), Li W*. (NaPO3)6-assisted formation of dispersive casein-amorphous   calcium phosphate nanoparticles: An excellent platform for curcumin delivery.Journal of Drug Delivery   Science and Technology. 2020;55: 101412 (IF:2.734)

(15)   Niu B, Jia J, Wang H, Chen S, Cao W, Yan J, Gong X, Lian X, Li W*, Fan YY*(范彦英). In vitro and in   vivo release of diclofenac sodium-loaded Sodium alginate/carboxymethyl   chitosan-ZnO hydrogel beads. Int. J. Biol. Macromol. 2019;Dec   01;141 (IF:5.162)

(16)   Fan YY(范彦英)*,Nan F, Guo BL, Liao Y, Zhang MS, Guo J, Niu BL, Liang YQ, Yang CH, Zhang Y, Zhang XP, Pang XF. Effects of long-term rapamycin treatment on glial scar   formation after cryogenic traumatic brain injury in mice. Neuroscience Letters. 2018;678:68-75. (IF:2.274)

(17)   Fan YY(范彦英), Hu WW, Nan F, Chen Z*. Postconditioning-induced   neuroprotection, mechanisms and applications in cerebral ischemia. Neurochemistry International. 2017;107:43-56. (IF:3.881)

(18)   Fan YY(范彦英)#, Shen Z#, He P#,   Jiang L, Hou WW, Shen Y, Zhang XN, Hu WW, Chen Z. A novel neuroprotective strategy for   ischemic stroke: transient mild acidosis treatment by CO2 inhalation at   reperfusion.Journal   of cerebral blood flow & metabolism. 2014;34:275-283. SCI (IF:5.407, F1000收录)

(19)   Fan YY(范彦英)#, Zhang XN#, He P#,   Shen Z, Shen Y, Wang XF, Hu WW, Chen Z. Transient lack of glucose but not o2   is involved in ischemic postconditioning-induced neuroprotection. CNS Neuroscience &   Therapeutics. 2013;19:30-37. (IF:3.784)

(20)   Fan YY(范彦英)#, Hu WW#, Dai HB#, Zhang JX, Zhang LY, He P, Shen Y, Ohtsu H, Wei EQ, Chen Z. Activation of the central histaminergic   system is involved in hypoxia-induced stroke tolerance in adult mice. Journal of cerebral blood flow &   metabolism. 2011;31:305-314. (IF:5.008)

(21)     发明专利:一种AAV病毒在制备治疗脑外伤的药物上的用途(ZL202311670258.8),2023,申请人:范彦英,李妍,焦向英,成瑶,尹静,张舒涵,唐莉,杨彩红,张慧丰

(22)     发明专利:一种具有减轻药源性肾损伤的化合物及其用途(ZL202210812792.7),2023,发明人:杨彩红,范彦英,张成瑞,邱会琴,焦向英

(23)     实用新型专利:一种基于脑冷冻伤模型的冷冻装置(ZL202023308958.7),2021,申请人:范彦英,李宇,杨彩红

(24)     实用新型专利:一种细胞共培养支架(ZL202023308936.0),2021,申请人,范彦英,赵静,李妍

获奖及个人荣誉

(1)    2019年,荣获山西省“三晋英才”青年优秀人才称号

(2)      2011年,获陕西省科学技术奖一等奖;项目名称:神经源性组胺新作用的发现及其意义;授奖单位:陕西省人民政府;证书号:2011-1-31-R6; 6/11

研究生培养

目前已培养硕士研究生17名,博士研究生5名,多名同学获得博士/硕士研究生国家奖学金