代表性成果 （论文/专利/专著等） |
近年来，基于近红外二区（NIR-II）荧光成像技术，围绕临床转化与尖端科研开展深入研究，集NIR-II荧光设备改造、NIR-II荧光探针开发、NIR-II荧光数据分析于一体，掌握领域前沿的NIR-II荧光成像技术，积累了丰厚的研究基础。始终坚持科研-临床紧密结合，快速转化。国内率先开发NIR-II荧光成像系统，现处于临床前手术导航实验阶段，充分证实引导肿瘤术中精准切除的有效性，进一步加快成像系统的临床转化步伐。开发包括手术导航、术中快速病理分析、内窥诊疗等一系列NIR-II荧光成像系统，并已开展相关临床试验。 发表SCI学术论文38篇，总IF：341.27，H指数15。其中SCI一区论文24篇，IF>10的SCI论文17篇，发表在Advanced Science（2篇），Small（4篇），Chemical Engineering Journal（2篇），Advanced Healthcare Materials（7篇），Materials Today Bio（3篇），ACS Applied Materials & Interfaces，Nanoscale（3篇）等国际期刊，得到国际同行专家的高度认可，其中8篇（7篇IF＞10）被邀请做封面文章，4篇被期刊评为年度Hot Article（Hot Papers）。主持承担国家自然科学基金（2项）、科技部中央引导地方科技发展资金项目、山西省自然基金、高校科技创新计划等省部级项目8项；作为学术骨干参研国家自然基金国际(地区)合作与交流项目、国家自然科学基金应急管理项目、山西省科技攻关项目等多项省部级以上基金研究工作。申请国家发明专利及实用新型专利27项，已授权专利23项。获得山西省科学技术合作奖，一等奖；华夏医学科技奖，二等奖；中国抗癌协会科技奖，二等奖。 代表性科研成果： 学术论文 (1) Pengmin Liu, Rong Dai, Juan Li, Lin Chen, Qi Liu, Yuhang Wang, Shichao Meng, Binyue Zhang, Jinxuan Li, Weiwei Kang, Ziliang Zheng, Ruiping Zhang. Simple theranostics nanoagent for precision suppression of tumor growth and Metastasis: A traditional fermented product having a novel functional breakthrough[J]. Chemical Engineering Journal, 2024. (SCI TOP一区，IF=15.10) (2) Xiaochun Zheng, Weiwei Kang, Yarong Jin, Xin Zhang, Wenxuan Wang, Dongsheng Li, Shutong Wu, Lin Chen, Shichao Meng, Rong Dai*, Ziliang Zheng*, and Ruiping Zhang*. In-situ GSH-responsive gas nanogenerator for active NIR-II FL/PA imaging and synergistic restoration the macrophage niche in rheumatoid arthritis[J]. Chemical Engineering Journal, 2024, 485, 150128. (SCI TOP一区，IF=15.10) (3) Lin Chen, Mingxin Zhao, Weiwei Kang, Lujie Yu, Chongqing Zhang, Shutong Wu, Xiaorui Song, Keqi Zhao, Yao Li, Qin Liu, Rong Dai*, Ziliang Zheng*, and Ruiping Zhang*. Endogenous Melanin and Hydrogen-Based Specific Activated Theranostics Nanoagents: A Novel Multi-treatment Paradigm for Rheumatoid Arthritis[J]. Advanced Science, 2024, 11(25), 2401046. (SCI TOP一区，IF=15.10) (4) Yarong Jin, Dongsheng Li, Xiaochun Zheng, Mengting Gao, Wenxuan Wang, Xin Zhang, Rong Dai, Weiwei Kang, Shutong Wu, Rong Dai*, Ziliang Zheng*, and Ruiping Zhang*, A Novel Activatable Nanoradiosensitizer for NIR-II Fluorescence Imaging-Guided Safe-dose Synergetic Chemoradiotherapy of Rheumatoid Arthritis[J]. Advanced Science, 2024, 11(17), 2308905. (SCI TOP一区，IF=15.10) (5) Shutong Wu, Mengting Gao, Lin Chen, Yuhang Wang, Xiaochun Zheng, Binyue Zhang, Juan Li, Dongsheng Li, Rong Dai, Ziliang Zheng*, and Ruiping Zhang*. A Multifunctional Nanoreactor-Induced Dual Inhibition of HSP70 Strategy for Enhancing Mild Photothermal/Chemodynamic Synergistic Tumor Therapy[J]. Advanced Healthcare Materials, 2024. 2400819. (SCI TOP一区，IF=10.00) (6) Jinxuan Li, Mengting Gao, Yuhang Wang, Wenxuan Wang, Shichao Meng, Xin Zhang, Chongqing Zhang, Pengmin Liu, Ziliang Zheng*, and Ruiping Zhang*, NIR-II Absorption/Emission Dual-Function-Based 2D Targeted Nanotheranostics for Tunable Hydrogenothermal Therapy[J]. Advanced Healthcare Materials, 2024, 2401060. (SCI TOP一区，IF=10.00) (7) Chongqing Zhang, Dongsheng Li, Xin Zhang, Rong Dai, Weiwei Kang, Yao Li, Qin Liu, Mengting Gao, Ziliang Zheng*, Ruiping Zhang* and Zhaohui Wen*. Dual Regulation of Osteosarcoma Hypoxia Microenvironment by a Bioinspired Oxygen Nanogenerator for Precise Single-Laser Synergistic Photodynamic/Photothermal/Induced Antitumor Immunity Therapy[J]. Materials Today Bio, 2024, 26, 101054. (SCI TOP一区，IF=8.20) (8) Wenxuan Wang, Weiwei Kang, Xin Zhang, Xiaochun Zheng, Yarong Jin, Zhuo Ma, Yuhang Wang, Rong Dai, Xun Ma*, Ziliang Zheng*, and Ruiping Zhang*, Microenvironment-Responsive Targeted Nanomedicine for a Novel Collaborative Integration of Tumor Theranostics and Bone Defect Repair[J]. Advanced Healthcare Materials, 2024, 2400715. (SCI TOP一区，IF=10.00) (9) Xin Zhang, Dongsheng Li, Wenxuan Wang, Xiaochun Zheng, Chongqing Zhang, Yarong Jin, Shichao Meng, Jinxuan Li, Rong Dai, Weiwei Kang, Hua Wu*, Ziliang Zheng*, and Ruiping Zhang*. A Novel NIR-II FL/ PA Imaging-Guided Synergistic Photothermal-Immune Therapy: Biomineralizing Nanosystems Integrated with Anti-tumor and Bone Repair[J]. Materials Today Bio, 2024, 26, 101052. (SCI TOP一区，IF=8.20) (10) Weiwei Kang, Yuhang Wang, Lei Xin, Lin Chen, Keqi Zhao, Lujie Yu, Xiaorui Song, Ziliang Zheng, Rong Dai*, Weiwei Zhang*, and Ruiping Zhang*. Biodegradable Cascade-Amplified Nanotheranostics for Photoacoustic-Guided Synergistic PTT/CDT/Starvation Anti-Tumor in the NIR-II Window[J]. Advanced Healthcare Materials, 2024, 2401459. (SCI TOP一区，IF=10.00) (11) Rong Dai, Mingxin Zhao, Xiaochun Zheng, Dongsheng Li, Huifang Hao, Xuejiao Chen, Yarong Jin, Juan Li, Weiwei Kang, Qin Liu, Ziliang Zheng*, and Ruiping Zhang*, Homology-Activated Ultrasensitive Nanomedicines for Precise NIR-II FL/MRI Imaging-Guided “knock-on” Dynamic Therapy in Rheumatoid Arthritis[J]. Advanced Healthcare Materials, 2024, 13(11), 2303892. (SCI TOP一区，IF=10.00) (12) Rong Dai, Qi Liu, Binyue Zhang, Xin Zhang, Mengting Gao, Dongsheng Li, Weiwei Kang, Lin Chen, Mingxin Zhao, Ziliang Zheng*, and Ruiping Zhang*, A single NIR-II laser-triggered self-enhancing photo/enzyme-coupled three-in-one nanosystems for breast cancer phototheranostics[J]. Advanced Healthcare Materials, 2023, 2302783. (SCI TOP一区，IF=10.00) (13) Ziliang Zheng, Xuejiao Chen, Yanchun Ma, Rong Dai, Shutong Wu, Tong Wang, Jun Xing, Jinnan Gao, and Ruiping Zhang*. Dual H2O2-Amplified Nanofactory for Simultaneous Self-Enhanced NIR-II Fluorescence Activation Imaging and Synergistic Tumor Therapy[J]. Small, 2022, 2203531. (SCI TOP一区，IF=15.15) (14) Ziliang Zheng, Xuejiao Chen, Rong Dai, Shutong Wu, Weiwei Kang, YuFei Qin, Shilei Ren, and Ruiping Zhang*. Cyclic Enhancement of Hypoxic Microenvironment via An Intelligent Nanoamplifier for Activated NIR-II Fluorescence/Photoacoustic Imaging-Guided Precise Synergistic Therapy. [J]. Materials Today Bio, 2022, 100478. (SCI TOP一区，IF=10.76) (15) Ziliang Zheng, Ailin Duan, Rong Dai, Yao Li, Xuejiao Chen, YuFei Qin, Shilei Ren, Ran Li,* Zhen Cheng,* and Ruiping Zhang*. A “Dual-Source, Dual-Activation” Strategy for NIR-II Window Theranostic Nanosystem Enabling Optimal Photothermal-Ion Combination Therapy.[J]. Small, 2022, 2201179. (SCI TOP一区，IF=15.15) (16) Ziliang Zheng, Zhuo Jia, Yufei Qin, Rong Dai, Xuejiao Chen, Yanchun Ma, xianmei Xie, Ruiping Zhang*. All-in-One Zeolite-Carbon-Based Nanotheranostics with Adjustable NIR-II Window Photoacoustic/Fluorescence Imaging Performance for Precise NIR-II Photothermal-Synergized Catalytic Antitumor Therapy[J]. Small, 2021, 17(41): 2103252. (SCI TOP一区，IF=15.15) (17) Ziliang Zheng, Zhuo Jia, Chunrong Qu, Rong Dai, Yufei Qin, Shuo Rong, Yulong Liu, Zhen Cheng*, Ruiping Zhang*. Biodegradable Silica-Based Nanotheranostics for Precise MRI/NIR-II Fluorescence Imaging and Self-Reinforcing Antitumor Therapy[J]. Small, 2021, 17(10): 2006508. (SCI TOP一区，IF=15.15) (18) Ziliang Zheng, Rong Dai, Zhuo Jia, Yufei Qin, Shuo Rong, Xiaoyang Peng, Xianmei Xie, Ruiping Zhang*. A Biodegradable Multifunctional Nanotheranostic Based on Ag2S-Doped Hollow BSA-SiO2 for Enhancing ROS-Feedback Synergistic Antitumor Therapy[J]. ACS Applied Materials &Interfaces, 2020, 12(49): 54356-54366. (SCI TOP一区，IF=10.38) (19) Ziliang Zheng, Qi Chen, Shuo Rong, Rong Dai, Zhuo Jia, Xiaoyang Peng, Ruiping Zhang*. Two-stage activated nano-truck enhanced specific aggregation and deep delivery for synergistic tumor ablation[J]. Nanoscale, 2020, 12(29): 15845-15856. (SCI TOP一区，IF=8.31) (20) Ziliang Zheng, Qi Chen, Rong Dai, Zhuo Jia, Chenhua Yang, Xiaoyang Peng, Ruiping Zhang*. A continuous stimuli-responsive system for NIR-II fluorescence/photoacoustic imaging guided photothermal/gas synergistic therapy[J]. Nanoscale, 2020, 12, 11562-11572. (SCI TOP一区，IF=8.31) (21) Ziliang Zheng, Chen Sun, Rong Dai, Shiyao Wang, Xu Wu, Xia An, Xianmei Xie*, Organotemplate-free synthesis of hollow Beta zeolite supported Pt-based catalysts for low-temperature ethanol steam reforming, Catalysis Science & Technology, 2016, 6(17): 6472-6475. (SCI 二区，IF=6.18) (22) Ziliang Zheng, Donghua Yang, Tingting Li, Xuemei Yin, Shiyao Wang, Xu Wu, Xia An, Xianmei Xie*, A novel BEA-type zeolite core-shell multiple catalyst for hydrogen-rich gas production from ethanol steam reforming, Catalysis Science & Technology, 2016, 6(14): 5427-5439. (SCI 二区，IF=6.18) (23) Ziliang Zheng, Chen Sun, Rong Dai, Shiyao Wang, Xu Wu, Xia An, Xianmei Xie*, Ethanol steam reforming on Ni-based catalysts: Effect of Cu and Fe addition on the catalytic activity and resistance to deactivation, Energy & Fuels, 2017, 31(3): 3091-3100. (SCI TOP二区，IF=4.65) (24) Shutong Wu, Lin Chen, Weiwei Kang, Qin Liu, Mengting Gao, Dongsheng Li, Yao Li, Rong Dai, Ziliang Zheng*, Recent developments of fluorescence imaging technology in the second near-infrared window, Biomedical Engineering Communications, 2022, 1(1): 3. (25) 郑子良、曲波涛、杨晓荣、刘玲、张瑞平，肿瘤靶向Pt-Cu基纳米平台用于近红外二区光声成像引导的光热治疗，无机化学学报，2021，37(11)，1991-2001. (SCI 四区，IF=0.83) (26) Rong Dai#, Ziliang Zheng#, Wenjun Yan, Chenshuai Lian, Xu Wu, Xia An, Xianmei Xie*, Dragon fruit-like Pt-Cu@mSiO2 nanocomposite as an efficient catalyst for low-temperature ethanol steam reforming, Chemical Engineering Journal, 2020, 379: 122299. (SCI TOP一区，IF=16.74) (27) Rong Dai#, Ziliang Zheng#, Chenshuai Lian, Kai Shi, Xu Wu, Xia An, Xianmei Xie*. A sinter-resistant catalytic system based on ultra-small Ni-Cu nanoparticles encapsulated in Ca-SiO2 for high-performance ethanol steam reforming[J]. Nanoscale, 2020, 12(31): 16605-16616. (SCI TOP一区，IF=8.31) (28) Rong Dai#, Ziliang Zheng#, Kai Shi, Xu Wu, Xia An, Xianmei Xie, A multifunctional core-shell nanoreactor with unique features of sintering resistance for high-performance ethanol steam reforming reaction[J]. Fuel, 2020, 119514. (SCI TOP一区，IF=8.03) (29) Rong Dai#, Ziliang Zheng#, Chenshuai Lian, Xing Li, Xu Wu, Xia An, Xianmei Xie, A high-performance CeO2@Pt-Beta yolk-shell catalyst used in low-temperature ethanol steam reforming for high-purity hydrogen production[J]. International Journal of Energy Research, 2019, 43(6): 2075-2085. (SCI TOP二区，IF=4.67) (30) Rong Dai#, Ziliang Zheng#, Chen Sun, Xing Li, Shiyao Wang, Xu Wu, Xia An, Xianmei Xie*, Pt nanoparticles encapsulated in a hollow zeolite microreactor as a highly active and stable catalyst for low-temperature ethanol steam reforming, Fuel, 2018, 214: 88-97. (SCI 一区，IF=8.03) (31) Qi Chen#, Ziliang Zheng#, Xiaojing He, Shuo Rong, Yufei Qin, Xiaoyang Peng, Ruiping Zhang*. A Tumor‐targeted Theranostic Nanomedicine with strong absorption in the NIR-II Biowindow for Imaging-Guided Multi-gradient Therapy[J]. Journal of Materials Chemistry B, 2020. (SCI 二区，IF=7.57) (32) Yufei Qin#, Ziliang Zheng#, Xuejiao Chen, Qin Liu, Shilei Ren, Weiwei Zhang, Ailin Duan, Ruiping Zhang*. Tumor Microenvironment‐Activated Nanosystem with High Aggregation and On‐Demand Degradation for Imaging‐Guided Synergistic Hydrogenothermal Therapy[J]. Advanced Therapeutics, 2022, 2200056. (SCI 二区，IF=5.01) (33) Jia Zhuo#, Rong Dai#, Ziliang Zheng#, Qin Yufei, Zhang Ruiping*. Hollow carbon-based nanosystem for photoacoustic imaging-guided hydrogenothermal therapy in the second near-infrared window[J]. RSC Advances, 2021, 11(20): 12022-12029. (SCI 三区，IF=4.04) (34) Shilei Ren#, Rong Dai#, Ziliang Zheng#, Xuejiao Chen, Shutong Wu, Ruiping Zhang,* and Zhiguo Gui*. Multifunctional AuPd-Cluster Nanotheranostics with Cascaded Self-Regulating Redox Tumor-Microenvironment for Dual-Photodynamic Synergized Enzyme Catalytic Therapy[J]. Journal of Materials Chemistry B, 2022. DOI: 10.1039/D2TB02096C. (SCI 二区，IF=7.57) (35) Shilei Ren#, Rong Dai#, Ziliang Zheng#, Qin Liu, Xiaochun Zheng, Juan Li, Shutong Wu, Ruiping Zhang,* and Zhiguo Gui*. A novel bidirectional perfusion-like administered system for NIR-II fluorescence imaging precision diagnosis of bladder cancer[J]. Nanomedicine: Nanotechnology, Biology, and Medicine, 2023. (SCI 二区，IF=6.46) (36) Ling Liu#, Shangpo Yang#, Ziliang Zheng#, Qingshuang Li, Chenchen Liu, Dehong Hu, Zhou Liu, Xiaoping Zhang, Ruiping Zhang,* and Duyang Gao*. Biomimetic Theranostic Agents with Superior NIR-II Photoacoustic and Magnetic Resonance Imaging Performance for Targeted Photothermal Therapy of Prostate Cancer[J]. Pharmaceutics, 2023, 15(6): 1617.(SCI 二区，IF=6.53) (37) Wang J, Yu Y, Zhang C, Ziliang Zheng, and Weihong Yan. New advances in diagnosis and treatment of nano drug delivery systems across the blood-brain barrier[J]. Nanocomposites, 2023, 9(1): 116-127.(SCI 二区，IF=4.20) (38) Fan B, Liu L, Wu Q, Ziliang Zheng, and Ruiping Zhang*. of Lactoferrin-mediated Copper Sulfide Nanoparticle and Its Photothermal Ablation for Tumor Therapy [J]. Chinese Journal of Analytical Chemistry, 2023, 51(2): 239-249.(SCI 四区，IF=1.20) 发明专利 (1) 郑子良，张瑞平，郑晓春，代蓉，康伟伟，李东升，李耀；一种响应型类风湿性关节炎气体纳米发生器及其制备方法与应用，2024-02-04，中国，202410158670.X (2) 张瑞平，郑子良，靳雅荣，代蓉，李东升，郑晓春，吴疏桐，赵铭欣；一种肿瘤微环境响应降解型纳米探针及其制备方法与应用，2024-03-29，中国，202410372310.X (3) 郑子良，张瑞平，李金轩，吴华，代蓉，康伟伟，郜梦婷，刘琴；一种诊疗一体化纳米探针及其制备方法和应用，2024-02-04，中国，202410158695.X (4) 郑子良，张瑞平，王文轩，马卓，刘琴，郜梦婷，郑晓春；一种具有骨组织深层递送能力的荧光探针及其制备方法和应用，2024-02-04，中国，202410158629.2 (5) 郑子良，赵科奇，康伟伟，陈霖，赵铭欣，余璐婕；一种用于类风湿关节炎诊疗一体化响应型纳米探针，2023-10-31，中国，202311431226.2 (6) 李耀，张瑞平，郑子良，代蓉，康伟伟，刘琴，郜梦婷；李东升；一种基于频率编码的近红外荧光成像设备，2023-03-15，中国，202320500343.9 (7) 张瑞平，郑子良，王文轩，马迅，王宇航，代蓉，马卓；一种诊疗一体化纳米探针及其制备方法和应用，2023-02-24，中国，202310163601.3 (8) 郑子良，张瑞平，靳雅荣，李娟，刘琪，康伟伟，刘琴；一种响应型类风湿性关节炎纳米探针及其制备方法与应用，2023-02-20，中国，202310137985.1 (9) 张瑞平，李耀，郑子良，代蓉，康伟伟，刘琴，郜梦婷，李东升；基于时间滤波的近红外荧光成像术中导航系统及导航方法，2023-02-16，中国，202310124694.9 (10) 康伟伟，张瑞平，王宇航，郑子良，代蓉，吴疏桐；一种具有近红外二区光发射特性的生物质衍生碳纳米粒子及其制备方法与应用，2022-11-28，中国，202211498252.2 (11) 郑子良，张瑞平，陈雪娇，陈琪，郑晓春，吴疏桐；一种可激活型诊疗一体化纳米探针及其制备方法和应用，2022-07-13，中国，202210828291.8 (12) 郑子良，张瑞平，段艾林，辛磊，程震；一种肿瘤微环境响应型诊疗一体化纳米探针的制备及应用，2022-04-13，中国，202210394577.X (13) 郑子良，张瑞平，贾卓，秦宇飞，段艾林；一种新型NIR-Ⅱ诊疗一体化硅-碳纳米探针及其制备方法，2020-11-26，中国，ZL202011347696.7 (14) 郑子良，张瑞平，贾卓，陈琪，杨晓荣，一种降解型棒状介孔二氧化硅纳米材料的一步合成法，2020-11-26，中国，202011347705.2 (15) 张瑞平，郑子良，贾卓，陈琪，陈雪娇；肿瘤微环境响应降解型诊疗一体化纳米探针及制备方法，2020-11-26，中国，ZL202011347708.6 (16) 张瑞平，郑子良，陈琪，秦宇飞，段艾林；肿瘤靶向型光声成像引导多阶段治疗纳米探针及制备方法，2019-09-04，中国，ZL202010921912.8. (17) 郑子良，张瑞平，贾卓，赵振祥，谢鲜梅；一种球状空心介孔硫化铋/二氧化硅纳米材料的一步合成法，2019-07-01，中国，ZL201910583397.4. (18) 张瑞平，郑子良，陈琪，张重庆，罗伟，赵振祥；一种肿瘤微环境响应降解型诊疗一体化纳米探针及制备方法，2019-06-12，中国，ZL201910504344.9. (19) 谢鲜梅，郑子良，孙晨，代蓉，王诗瑶，吴旭，安霞；乙醇水蒸气重整制氢球状空心催化剂及其制备方法，2018-12-18，中国，ZL201610544870 .4. (20) 谢鲜梅，代蓉，郑子良，连晨帅，王诗瑶；一种介孔二氧化硅包覆式铂铜合金催化剂及其制备方法，2018-11-24，中国，201811410727.1 (21) 郑子良，谢鲜梅，代蓉；孙晨，王诗瑶，吴旭，安霞；应用乙醇水蒸气重整反应的微型反应器及其制备方法，2018-01-02，中国，ZL201610544869.1. (22) 谢鲜梅，郑子良，孙晨，代蓉，王诗瑶，吴旭，安霞；空心Beta分子筛的制备方法，2017-09-29，中国，ZL201610544872.3. (23) 郑子良，谢鲜梅，杨冬花，代蓉，王诗瑶；一种核壳结构Beta分子筛及其制备方法，2017-04-19，中国，ZL201510366545.9. (24) 谢鲜梅，孙晨，郑子良，王诗瑶，吴旭，安霞；含稀土氧化物多功能核壳材料及其制备方法，2016-11-24，中国，201611042609.0 (25) 谢鲜梅，郑子良，杨冬花，代蓉，王诗瑶；一种同晶相核壳结构β分子筛的制备方法，2016-08-17，中国，ZL201510151336.2. (26) 谢鲜梅，王诗瑶，郑子良，孙晨，贺博，吴旭，安霞；微-介孔结构Beta分子筛的制备方法，2016-07-12，中国，201610544871.9 (27) 杨冬花，郑子良，代蓉，杨瑞娟，郭超，武正簧，李晓峰，窦涛；一种多级孔道复合分子筛吸附剂的制备方法，2015-12-09，中国，ZL201410151088.7. |
