出 生 年

1970.4

系/教研室

山西医科大学/基础医学院

职    称

主任技师

职    务

科主任

导师类型

学术型

最高学历/学位/毕业院校

研究生/硕士/山西医科大学

E-mail

sunruifang@sxmu.edu.cn

学科专业

医学技术（病理）

研究方向

肿瘤分子标志物研究

工作单位

山西省肿瘤医院

人才称号/学术兼职

山西省抗癌协会肿瘤样本整合研究专业委员会 主任委员

学习工作经历

教育经历

1.           2017.7-2018.6 哈佛医学院全球临床学者科研训练项目，医学统计及流行病学方向学习结业

2.           2015.1-2016.1 美国德克萨斯大学MD Anderson 癌症中心，血液病理，访问学者

3.           2001.9-2004.6  山西医科大学， 免疫学，硕士研究生

4.           1990.9-1993.7 山西职工医学院，医学检验，大专

5.           1985.9-1988.7 山西省晋中地区卫生学校，医学检验，中专

工作经历

1.           2017.9-至今   山西省肿瘤医院 肿瘤生物样本库副主任（主持工作）、主任，副主任技师、主任技师

2.           2007.2-2017.8 山西省肿瘤医院 病理科，副主任技师

3.           2004.8-2007.1 太钢总医院 检验科，副主任，副主任技师

4.           1995.9-2004.6 太钢胜利医院（现山西省烧伤救治中心），主管技师

5.           1988.7-1994.3 山西省灵丘县人民医院，技士、技师

主持的科研

/教学项目

(1)  肿瘤细胞外泌体携载LncRNA SNHG12调控免疫细胞浸润在弥漫大B细胞淋巴瘤免疫治疗中的机制研究（SD2023006），山西省肿瘤医院区域医疗中心科教培育基金，在研，主持，20万；

(2)  MYC基因异常在弥漫大B细胞淋巴瘤中的转化医学研究（201803D421054），山西省科技厅重点研发计划项目（国际科技合作方面），结题，主持，15万。

代表性成果

（论文/专利/专著等）

1.            Huilin Cui^#, Qianqian Yu^#, Qumiao Xu^#, Chen Lin^#,   Long Zhang, Wei Ye, Yifei Yang, Sijia Tian, Yilu zhou, Runzhe Sun, Yongsheng   Meng, Ningning Yao, Haizhen Wang, Feilin Cao, Meilin Liu, Jinfeng Ma, Cheng   Liao*, Ruifang Sun*. EGFR and MUC1 as dual-TAA drug targets for   lung cancer and colorectal cancer. Frontiers in Oncology. 2024,   Nov 27. Published online.

2.            Ke Gong^#, Jiantao Lin^#, Xiaoyan Chen^#,   Yi Duan, Jiali Zhang, Jian Yu, Jing Wang, Ruifang sun*, Jie   Li*, Yourong Duan*. Thermosensitive gel-nano system against esophageal   cancer via restoring p53 activity and boosting T-cell immunity. Journal   of Controlled Release. 2024 July;371:111-125

3.            Yong   Zhou^#, Shanlan Mo^#, Heyang Cui^#,   Ruifang Sun^#, Weimin Zhang^#, Xiaofei Zhuang^#, Enwei Xu, Hongyi Li, Yikun Cheng,   Yongsheng Meng, Meilin Liu, Ting Yan, Huijuan Liu, Ling Zhang, Bin Yang,   Yanfeng Xi, Shubin Wang, Xiaolong Cheng, ShuaiCheng Li, Zhihua Liu*, Qimin   Zhan*, Zheng Hu*, Yongping Cui*. Immune-tumor interaction dictates   spatially directed evolution of esophageal squamous cell carcinoma.   National Science Review. 2024 Apr;11(5): nwae150

4.            Heyang   Cui^#, Yong Zhou^#, Fang Wang^#,   Caixia Cheng^#, Weimin Zhang^#, Ruifang Sun^#, Ling Zhang, Yanghui Bi, Min Guo ,   Yan Zhou, Xinhui Wang, Jiaxin Ren, Ruibing Bai, Ning Ding, Chen Cheng,   Longlong Wang, Xuehan Zhuang, Mingwei Gao, Yongjia Weng, Yueguang Wu, Huijuan   Liu, Shuaicheng Li, Shubin Wang, Xiaolong Cheng, Yongping Cui*, Zhihua Liu*,   Qimin Zhan*. Characterization of somatic structural variations in 528   Chinese individuals with Esophageal squamous cell carcinoma. Nature   Communications. 2022 Oct;13 (1): 6296

5.            Jian Qi^#, Bo Hong^#, Shujie Wang^#,   Jingyun Wang, Jinman Fang, Ruifang Sun* Jinfu Nie*, Hongzhi Wang*. Plasma   cell-free DNA methylome-based liquid biopsy for accurate gastric cancer   detection. Cancer Science. 2024 Oct; 115(10): 3426-3438.

6.            Wenting   Cui^#, Cancan Luo^#, Lili Zhou^#,   Tiantian Yu, Yongsheng Meng, Qianqian Yu, Zhixiang Lei, Ya Wang, Lijuan Peng,   Qingqing Luo, Duozhuang Tang, Ruifang Sun*, Li Yu*. Roles of RNA   m5C modification patterns in prognosis and tumor microenvironment   infiltration of diffuse large B-cell lymphoma. Am J Cancer Res. 2024;14   (4), 1768-1783

7.            Yiyin Zhang^#, Yongming Yang^#, Jiayi Zhou^#，Qianqian   Yu, Lixia Chen, Lili Zhao, Yongsheng Meng, Jing Wang, Lei Yan, Ziyang Huang，Shucheng   Song，Wenqi Bai*，Ruifang Sun*, Xihua Yang*. Patient-derived tumor xenograft animal model   of gastric cancer in precision chenmotherapy. Naunyn-Schmiedeberg’s Archives   of Pharmacology. 2025, Published online.

8.            Ningning   Yao^#, Qing Hou^#, Yu Liang, Xin Cao, Bochen Sun, Lijuan   Wei, Ruifang Sun*, Jianzhong Cao*. Serum aspartate   aminotransferase, a novel potential biomarker of prognosis in extranodal   natural killer/T cell lymphoma, nasal type. Cancer Biomark. 2024; 39(4): 265-275.

9.            陈美茹，姚宁宁，孙润哲，唐 洁，刘如丽，于倩倩，孙瑞芳*. 肺腺癌中STED7的表达及其临床意义. 临床与实验病理学杂志. 2023；39（7）:   816-821

10.       Su H^#, Chang   J, Xu M, Sun R*, Wang J*. CDK6 overexpression   resulted from microRNA?320d downregulation promotes cell proliferation in   diffuse large B?cell lymphoma. Oncology Reports. 2019   Jul;42(1):321-327

11.       Li L^#,   Sun R^#，Miao   Y^#, et al. PD-1/PD-L1 expression and interaction by Automated   Quantitative Immunofluorescent Analysis show adverse prognostic impact in   diffuse large B-cell lymphoma patients with T cell infiltration: a study from   the International DLBCL Consortium Program. Modern Pathology.   2019 Jun; 32(6):741-754

12.       Wang   X^#, Cao X^#, Sun R^#, et al. . Clinical   Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De   Novo Diffuse Large B-Cell Lymphoma. Neoplasia. 2018 Jun; 20(6):574-593.

13.       Sun   R*,   Yu Q, Young KH*. Critically Dysregulated Signaling Pathways and Clinical   Utility of Pathway Biomarkers in Lymphoid Malignancies. Chronic Diseases and   Translational Medicine. 2018; 4:29-4

14.       Sun   R,   Wang J, Young KH*. Oncogenic Signaling Pathways and Pathway-Based   Therapeutic Biomarkers in Lymphoid Malignancies. Crit Rev Oncog. 2017;   22(5-6):527-57

15.         Sun   R,   Medeiros LJ, Young KH*. Diagnostic and predictive biomarkers for lymphoma   diagnosis and treatment in the era of precision medicine. Modern   Pathology. 2016; 29(10):1118-42

16.         孙瑞芳, Harald Stein*, 王晋芬*. 2016年版 WHO 淋巴瘤分类新进展及其应用. 白血病·淋巴瘤. 2016; 25(6): 321-325

获奖及个人荣誉

(1)        孙瑞芳(5/6);   基于基因组异质性的食管鳞癌相关标志物及治疗靶点筛选, 山西省人民政府, 自然科学, 省部一等奖, 2024(崔永萍; 张玲; 程彩霞; 杨斌; 孙瑞芳; 庄晓飞) (科研奖励)

(2)        孙瑞芳(7/8);   3q27和8q24基因，2153Da和 3156Da蛋白在弥漫大B细胞淋巴瘤分子分型中的意义, 山西省科技厅, 科技进步, 省部二等奖, 2013(王晋芬;   张宏伟; 王卫东; 杨瑞红; 彭文岗; 白玮; 孙瑞芳; 郗彦凤) (科研奖励)

研究生培养

已毕业研究生4名

在读研究生3名