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申报中华预防医学会科学技术奖项目公示

发布时间:2023/04/14 11:12:25     点击:186

 

我单位牛侨老师完成的“铝作业工人认知功能损害的职业人群调查和毒作用机制实验研究”项目申报2023年中华预防医学会科学技术奖,特进行公示。公示期: 2023 4 14 日至 2023 4 20 日,公示期内如对公示内容有异议,请您向山西医科大学科学技术部反映。

联系人及联系电话:王静  0351-3985329

 

 

2023414

 

公示内容

一、项目名称:铝作业工人认知功能损害的职业人群调查和毒作用机制实验研究

二、推荐单位及推荐意见:

推荐单位:山西医科大学

推荐意见:众所周知,铝在人们日常生活中用途广泛,用量极大。本项目着眼于中国铝生产量大、用铝量大的基本国情,着重研究铝对铝作业工人的损伤,保护铝作业工人身体健康,为制定铝作业工人的职业病筛查标准具有重大意义。该项目研究发现的铝导致神经细胞程序性坏死为全球首次,具有重大创新性与先进性。发现的铝导致工人视空间记忆能力下降为职业损伤判断标准提供了依据,因此该项目的研究成果具有重大现实意义。该项目多篇论文发表于Q1与Q2分区的高水平学术杂志,其研究成果辐射了全球多个国家和地区,对该行业有一定的影响力,有助于该领域的科技进步。

三、项目简介:(项目简要介绍,技术路线,创新点及项目产出。)

铝是地壳含量丰富的金属元素,仅次于类金属硅,用途广泛,用量极大。我国已经连续十余年是世界上最大的铝生产国和使用国,据国际铝组织(www.world-aluminium.org/)统计,我国仅2019年5月-2021年5月金属铝产量占全球产量57.1%,达13595.5万吨,铝生产直接从业者达400万,职业暴露人口众多。铝具有神经毒性,被认为与认知功能损害甚至与阿尔兹海默病有关,但尚缺乏有力证据。本项目基于铝暴露职业人群,进行了多次大人群流行病学调查,证实了职业性铝暴露确实引起工人认知功能下降,而且与血铝水平相关。基于本团队对铝的神经毒性作用机制的科学假设,我们进行了系统的实验研究,多手段、多方位、多角度阐明了铝的神经毒性作用机制;又将毒作用机制中的某些环节在职业人群研究中加以验证。在前期研究(2000-2009)的基础上,本项目基本阐述清楚了铝的神经毒作用机制,主要从职业铝暴露人群发现认知功能损害和血液淋巴细胞tau蛋白过度磷酸化,再进行大人群研究验证铝致多领域认知功能损害,发现铝暴露水平和认知功能损害的剂量反应关系,血液中铝浓度升高的同时锌浓度降低,并且发现职业铝暴露人群血液淋巴细胞全基因组甲基化降低。在实验室研究中着重探讨了铝致神经细胞凋亡和程序性坏死的细胞信号通路和机制。并且采用阻断手段验证两种细胞死亡方式的存在,尤其铝致神经细胞程序性坏死是本项目的独特发现,为国际首次。本项目在实验室研究中探索了铝降低神经突触可塑性的机制和关键蛋白,并在铝作业人群血液淋巴细胞得到验证。由于人脑的不可及性,一般对认知功能损害只有用认知功能量表测试,无法探究损害机制;本项目发现铝作业工人血液淋巴细胞tau蛋白过度磷酸化和降低神经突触可塑性的信号通路蛋白分子,为研究人群认知功能损害提供了新的思路和方法,具有明显创新性。本项目一个明显特点是从人群发现问题,实验室研究探索机制,再回到人群验证。在职业环境中,工人以吸入多为纳米级的铝氧化物微细颗粒为主。而且纳米氧化铝越来越多地得到应用。本项目对纳米氧化铝的神经毒性、基因毒性及神经发育毒性进行了探讨,为这一领域的研究进行了开创性的工作。本项目共发表SCI论文72篇,其中20篇代表性论文他引358次。项目带头人受邀多次在国际和国内学术会议作报告。论文对于阐明铝导致认知功能损害作用机制提供了丰富而科学的依据,为科学家群体深入探讨铝的神经毒性及阿尔兹海默病病因和危险因素提供了资料,为保护铝作业人群身体健康做出了贡献。

四、主要支撑材料目录(被引用论文题目及作者)

序号

论文题目

论文作者

1

Increased aluminum and lithium and decreased zinc levels in plasma is related to cognitive impairment in workers at an aluminum factory in China: A cross-sectional study

Shang, N (Shang, Nan); Zhang, L (Zhang, Lan); Wang, S (Wang, Shuo); Huang, T (Huang, Tao); Wang, YH (Wang, Yanhong); Gao, XC (Gao, Xiaocheng); Xu, SM (Xu, Shimeng); Zhang, JQ (Zhang, Jingqi); Zhang, L (Zhang, Ling); Niu, Q (Niu, Qiao); Zhang, QL (Zhang, Qinli)

2

Aluminum-Induced Cognitive Impairment and PI3K/Akt/mTOR Signaling Pathway Involvement in Occupational Aluminum Workers

Shang, N (Shang, Nan); Zhang, P (Zhang, Ping); Wang, S (Wang, Shuo); Chen, JP (Chen, Jianping); Fan, R (Fan, Rong); Chen, J (Chen, Jin); Huang, T (Huang, Tao); Wang, YH (Wang, Yanhong); Duncan, J (Duncan, Jeremy); Zhang, L (Zhang, Ling); Niu, Q (Niu, Qiao); Zhang, QL (Zhang, Qinli)

3

Aluminium-induced synaptic plasticity injury via the PHF8-H3K9me2-BDNF signalling pathway

Li, H (Li, Huan); Xue, XL (Xue, Xingli); Li, ZY (Li, Zhaoyang); Pan, BL (Pan, Baolong); Hao, YX (Hao, Yanxia); Niu, Q (Niu, Qiao)

4

Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway

Li, H (Li, Huan); Xue, XL (Xue, Xingli); Li, L (Li, Liang); Li, YQ (Li, Yaqin); Wang, YN (Wang, Yanni); Huang, T (Huang, Tao); Wang, YH (Wang, Yanhong); Meng, HX (Meng, Huaxing); Pan, BL (Pan, Baolong); Niu, Q (Niu, Qiao)

5

The Relationship between Plasma Al Levels and Multi-domain Cognitive Performance among In-service Aluminum-exposed Workers at the SH Aluminum Factory in China: A Cross-sectional Study

Wang, SS (Wang, Shanshan); Meng, HX (Meng, Huaxing); Shang, N (Shang, Nan); Guo, JH (Guo, Junhong); Zhang, T (Zhang, Ting); Zhang, SH (Zhang, Shuhui); Zhao, YQ (Zhao, Yuqing); Zhang, HF (Zhang, Huifang); Zhang, QL (Zhang, Qinli); Niu, Q (Niu, Qiao)

6

Exposure to Alumina Nanoparticles in Female Mice During Pregnancy Induces Neurodevelopmental Toxicity in the Offspring

Zhang, QL (Zhang, Qinli); Ding, Y (Ding, Yong); He, KH (He, Kaihong); Li, H (Li, Huan); Gao, FP (Gao, Fuping); Moehling, TJ (Moehling, Taylor J.); Wu, XH (Wu, Xiaohong); Duncan, J (Duncan, Jeremy); Niu, Q (Niu, Qiao)

7

Overview of the Relationship Between Aluminum Exposure and Health of Human Being

Niu, Q (Niu, Qiao)

8

Alumina at 50 and 13nm nanoparticle sizes have potential genotoxicity

Zhang, QL (Zhang, Qinli); Wang, HY (Wang, Haiyang); Ge, CC (Ge, Cuicui); Duncan, J (Duncan, Jeremy); He, KH (He, Kaihong); Adeosun, SO (Adeosun, Samuel O.); Xi, HX (Xi, Huaxin); Peng, HT (Peng, Huiting); Niu, Q (Niu, Qiao)

9

Caspase-3 is Involved in Aluminum-Induced Impairment of Long-Term Potentiation in Rats Through the Akt/GSK-3 beta Pathway

Zhang, HF (Zhang, Huifang); Yang, XJ (Yang, Xiaojuan); Qin, XJ (Qin, Xiujun); Niu, Q (Niu, Qiao)

10

The Relationship Between Cognitive Impairment and Global DNA Methylation Decrease Among Aluminum Potroom Workers

Yang, XJ (Yang, Xiaojuan); Yuan, YZ (Yuan, Yuzhou); Lu, XT (Lu, Xiaoting); Yang, J (Yang, Jin); Wang, LP (Wang, Linping); Song, J (Song, Jing); Nie, JS (Nie, Jisheng); Zhang, QL (Zhang, Qinli); Niu, Q (Niu, Qiao)

11

Effects of Aluminium on beta-Amyloid (1-42) and Secretases (APP-Cleaving Enzymes) in Rat Brain

Wang, LP (Wang, Linping); Hu, JL (Hu, Jiali); Zhao, Y (Zhao, Yue); Lu, XT (Lu, Xiaoting); Zhang, QL (Zhang, Qinli); Niu, Q (Niu, Qiao)

12

Cognitive Disorders and Tau-Protein Expression Among Retired Aluminum Smelting Workers

Lu, XT (Lu, Xiaoting); Liang, RF (Liang, Ruifeng); Jia, ZJ (Jia, Zhijian); Wang, H (Wang, Hao); Pan, BL (Pan, Baolong); Zhang, QL (Zhang, Qinli); Niu, Q (Niu, Qiao)

13

Effects of Exposure to Aluminum on Long-term Potentiation and AMPA Receptor Subunits in Rats in vivo

Song, J (Song Jing); Liu, Y (Liu Ying); Zhang, HF (Zhang Hui Fang); Zhang, QL (Zhang Qin Li); Niu, Q (Niu Qiao)

14

Caspase-3 Short Hairpin RNAs: A Potential Therapeutic Agent in Neurodegeneration of Aluminum-Exposed Animal Model

Zhang, QL (Zhang, Qinli); Li, N (Li, Na); Jiao, X (Jiao, Xia); Qin, XJ (Qin, Xiujun); Kaur, R (Kaur, Ramanjit); Lu, XT (Lu, Xiaoting); Song, J (Song, Jing); Wang, LP (Wang, Linping); Wang, JM (Wang, Junming); Niu, Q (Niu, Qiao)

15

Necrostatin-1 inhibits the degeneration of neural cells induced by aluminum exposure

Zhang, QL (Zhang Qinli); Li, MQ (Li Meiqing); Jiao, X (Jiao Xia); Xu, L (Xu Li); Guo, WL (Guo Weili); Ji, XL (Ji Xiuliang); Ji, JW (Ji Junwei); Yang, HL (Yang Hailan); Zhang, C (Zhang Ce); Niu, Q (Niu Qiao)

16

Aluminium-Maltolate-induced Impairment of Learning, Memory and Hippocampal Long-term Potentiation in Rats

Liang, RF (Liang, Rui-feng); Li, WQ (Li, Wei-qing); Wang, XH (Wang, Xiao-hui); Zhang, HF (Zhang, Hui-fang); Wang, H (Wang, Hong); Wang, JX (Wang, Jun-xia); Zhang, Y (Zhang, Yu); Wan, MT (Wan, Ming-tao); Pan, BL (Pan, Bao-long); Niu, Q (Niu, Qiao)

17

APP/PS1 TRANSGENIC MICE TREATED WITH ALUMINUM: AN UPDATE OF ALZHEIMER'S DISEASE MODEL

Zhang, QL (Zhang, Q. L.); Jia, L (Jia, L.); Jiao, X (Jiao, X.); Guo, WL (Guo, W. L.); Ji, JW (Ji, J. W.); Yang, HL (Yang, H. L.); Niu, Q (Niu, Q.)

18

IN VIVO TOXICITY OF NANO-ALUMINA ON MICE NEUROBEHAVIORAL PROFILES AND THE POTENTIAL MECHANISMS

Zhang, QL (Zhang, Q. L.); Li, MQ (Li, M. Q.); Ji, JW (Ji, J. W.); Gao, FP (Gao, F. P.); Bai, R (Bai, R.); Chen, CY (Chen, C. Y.); Wang, ZW (Wang, Z. W.); Zhang, C (Zhang, C.); Niu, Q (Niu, Q.)

19

NOVEL INTERVENTIONS TARGETING ON APOPTOSIS AND NECROSIS INDUCED BY ALUMINUM CHLORIDE IN NEUROBLASTOMA CELLS

Zhang, QL (Zhang, Q. L.); Niu, Q (Niu, Q.); Niu, PY (Niu, P. Y.); Ji, XL (Ji, X. L.); Zhang, C (Zhang, C.); Wang, L (Wang, L.)

 

20

BAX GENE SILENCING: A POTENTIAL INTERVENTION IN ALUMINUM-INDUCED NEURAL CELL DEATH

Zhang, QL (Zhang, Q. L.); Niu, Q (Niu, Q.); Niu, PY (Niu, P. Y.); Shi, YT (Shi, Y. T.); Liu, CY (Liu, C. Y.); Di Gioacchino, M (Di Gioacchino, M.); Zhang, L (Zhang, L.); Zhang, C (Zhang, C.); Braga, M (Braga, M.)

 


五、主要完成人及完成单位情况









六、主要完成单位及排名情况

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