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张红梅


张红梅

博士,教授,博士生导师,博士后合作指导教师,教学实验教学中心主任

Phone(O):0351-4135273

Email:hm.zhang@sxmu.edu.cn,zhhm_108@163.com

通信地址: 山西医科大学公共卫生学院,山西省太原市新建南路56号,030001

教育经历:

2003/09-2008/07,山西医科大学,劳动卫生与环境卫生学,博士

1998/09-2003/07,山西医科大学,预防医学,学士

工作经历:

2020/06-至今,山西医科大学公共卫生学院实验教学中心,主任

2019/01-至今,山西医科大学环境卫生学教研室,教授

2010/07-2018/12,山西医科大学环境卫生学教研室,副教授

2008/09-2010/06,山西医科大学环境卫生学教研室,讲师

学习经历:

2013/12-2014/12,美国辛辛那提大学医学院,访问学者

学术任职:

中国环境诱变剂学会环境与神经退行性疾病委员会委员,中国环境诱变剂学会生物标志物委员会青年委员,国家医师资格考试公共卫生类别试题开发专家委员会委员,中华预防医学会环境卫生分会青年委员,中华医学会公共卫生分会第十届委员会青年委员会委员,山西省青年科技人才协会生物与医药科学专业委员会常务理事,山西省优生科学协会常务委员,山西省科技厅专家,中国毒理学会会员,中国环境科学学会会员,山西省环境诱变剂学会会员,Human and experimental toxicology,Molecular Neurobiology等杂志的审稿人。

荣誉称号:

山西省高等学校优秀青年学术带头人(2011),山西省高等学校“131领军人才工程”优秀中青年拔尖创新人才(2013),山西省“三晋英才”青年优秀人才(2018),第19届山西青年五四奖章获得者。

教学情况:

为预防医学、临床医学、卫生检验检疫专业及医学相关专业本科生讲授《环境卫生学》、《预防医学》、《环境生物学》、《水质理化检验》、《公共卫生基本操作技能》等课程,为公共卫生研究生讲授《环境医学概论》。负责1门校级精品课程,主持校级教改项目3项,指导1项大学生创新创业校级项目,发表教学论文2篇,参与获得山西省教学成果奖(高等教育)二等奖1项。

研究领域:

1.环境和职业污染物的神经毒性;

2.职业人群的暴露监测与健康效应研究;

已指导全日制研究生16名,非全日制研究生7名,指导的硕士学位论文被评为山西省优秀硕士学位论文。近10年在国内核心期刊发表科研论文61篇,其中SCI收录论文16篇,累计影响因子为67,其中Top 1区2篇,2区8篇,论文单篇IF 9.776。

科研获奖:

获得山西省科学技术一等奖1项,中华预防医学会科学技术三等奖1项,中国金属学会冶金医学二等1项。

代表性科研项目:

1.国家自然科学基金面上基金项目,81973093,小胶质细胞极化-BDNF甲基化介导的突触重构在苯并[a]芘致认知功能障碍中的调控机制,2020/01-2023/12,主持

2.国家自然科学基金青年基金项目,81001258,ROS反馈环在哺乳期PBDEs暴露致大鼠神经发育毒性的机制研究,2011/01-2013/12,主持

3.山西省留学人员科技活动择优资助项目,2019028,小胶质细胞活化和极化调控的突触重构在苯并[a]芘致认知功能障碍中的机理研究,2019/07-2022/12,主持

4.山西省回国留学人员科研资助项目,2017-059,DNMTs-BDNF基因甲基化修饰在苯并[a]芘致认知功能损伤中的调控作用,2017/07-2020/07,主持

5.山西省基础研究计划项目,2013021033-3,多溴联苯醚神经发育毒性的体内实验研究,2013/01-2015/12,主持

代表性论著:

1.Hongmei Zhang#, Xiaorong Yang#, Xin Li, Yan Cheng, Huajun Zhang, Lijun Chang, Min Sun, Zhihong Zhang, Zemin Wang, Qiao Niu*, Tong Wang*. Oxidative and nitrosative stress in the neurotoxicity of polybrominated diphenyl ether-153: possible mechanism and potential antioxidation targeted intervention. Chemosphere, 2020, 238(2020) : 1-13 (1区,IF=5.778) [PMID: 31545211]

2.Zhenzhen Xu#, Hongyan Wu#,Hongmei Zhang, Jianying Bai, Zhihong Zhang*. Interleukins 6/8 and cyclooxygenase-2 release and expressionsare regulated by oxidative stress-JAK2/STAT3 signalingpathway in human bronchial epithelial cells exposed to particulate matter≤2.5μm. J Appl Toxicol. 2020; 1-9. (3区,IF=2.997)[PMID: 32212198]

3.Xin Li, Xiaorong Yang, Lijun Chang, Zemin Wang, Tong Wang, Zhihong Zhang, Jianying Bai, Ruifeng Liang, Qiao Niu,Hongmei Zhang*. Endoplasmic reticulum rather than mitochondria plays a major role in the neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology Letters, 2019, 311(2019):37-48. (2区,IF=3.360) [PMID: 31029751]

4.Xiaorong Yang#*,Hongmei Zhang#, Jinzi Wu, Litian Yin, Liang-Jun Yan, Ce Zhang*. Humanin attenuatesNMDA-induced excitotoxicity by inhibiting ROS-dependent JNK/p38 MAPK pathway. International Journal of Molecular Sciences. 2018, 19, 2982: 1-12.(3区,IF=3.687)[PMID: 30274308]

6.Hongmei Zhang#, Xiaorong Yang#, Huajun Zhang, Xin Li, Zhihong Zhang, Lifang Hou, Zemin Wang,Qiao Niu*, Tong Wang*. Neurotrophins and cholinergic enzyme regulated by calpain-2: new insights into neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology Letters, 2018, 291(2018): 29-38. (2区,IF=3.858). [PMID: 29621559]

7.Guofang Lu#, Jianguo Li,Hong-Mei Zhang, Xin Zhao, Liang-Jun Yan, Xiaorong Yang*.Role and possible mechanisms of Sirt1 in depression. Oxidative Medicine and Cellular Longevity. 2018, 2018:1-6. (2区,IF=4.593) . [PMID: 29643977]

8.Hongmei Zhang#, Kimberly Yolton, Glenys M. Webster, Xiaoyun Ye, Antonia M. Calafat, Kim N. Dietrich, Yingying Xu, Changchun Xie, Joseph M. Braun, Bruce P. Lanphear, Aimin Chen*. Prenatal and childhood perfluoroalkyl substances exposures and children's reading skills at ages 5 and 8 years. Environment International, 2018, 111: 224-231. (Top 1区,IF=7.088) [PMID: 29241079]

9.Hongmei Zhang#*, Lijun Chang, Huajun Zhang, Jisheng Nie, Zhihong Zhang, Xiaorong Yang, Ann M.Vuong, Zemin Wang, Aimin Chen, Qiao Niu. Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology Letters, 2017, 277(2017):41-53. (2区,IF=3.858). [PMID: 28559121]

10.Hongmei Zhang#, Kimberly Yolton, Glenys M. Webster, Andreas Sjödin, Antonia M. Calafat, Kim N. Dietrich, Yingying Xu, Changchun Xie, Joseph M. Braun, Bruce P. Lanphear, Aimin Chen*. Prenatal PBDE and PCB exposures and reading, cognition, and externalizing behavior in children.Environmental Health Perspectives. 2017, 125(4): 746-752. (Top 1区,IF=9.776). [PMID: 27385187]

11.Hongmei Zhang#*, Xin Li, Liping Ge, Jin Yang, Sun Jianya, Qiao Niu. Methylation of CpG island of p14(ARK), p15(INK4b) and p16(INK4a) genes in coke oven workers. Human and Experimental Toxicology. 2015, 34(2): 191-197(4区,IF=1.747).

12.Nie Ji-Sheng#,Zhang Hong-Mei, Zhao Jie, Liu Hui-Jun, Niu Qiao*.Involvement of mitochondrial pathway in benzo[a]pyrene-induced neuron apoptosis.Human and Experimental Toxicology. 2014, 33(3):240-250. (4区,IF=1.453).

13.Hong-Mei Zhang*, Xin Li, Ji-Sheng Nie, Qiao Niu. Lactation exposure to BDE-153 damages learning and memory, disrupts spontaneous behavior and induces hippocampus neuron death in adult rats. Brain Research, 2013, 1517: 44-56. (3区, IF=2.879).

14.Hong-Mei Zhang#, Ji-Sheng Nie, Xin Li, Qiao Niu*. Association of aryl hydrocarbon receptor gene polymorphism with the neurobehavioral function and autonomic nervous system function changes induced by benzo[a]pyrene exposure in coke oven workers. Journal of Occupational and Environmental Medicine. 2013, 55(3): 265-271 (4区,IF=2.062).

15.Hong-Mei Zhang#, Ji-Sheng Nie, Xin Li, Qiao Niu*. Characteristic analysis of peripheral blood mononuclear cell apoptosis in coke oven workers. Journal of Occupational Health. 2012, 54(1): 44-50. (4区,IF=1.634). [PMID: 22186298]

16.Qiao Niu#*,Hong-Mei Zhang, Xin Li, Meiqin Li. Benzo[a]pyrene-induced neurobehavioral function and neurotransmitter alterations in coke oven workers. Occupational and Environmental Medicine. 2010, 67(7): 444-448. (2区,IF=3.494)

17.Hong-Mei Zhang#, Ji-Sheng Nie, Fang Wang, Ying-Tao Shi, Ling Zhang, Andrea Antonucci, Hui-Jun Liu, Jing Wang, Jie Zhao, Qin-Li Zhang, Lin-Ping Wang, Jing Song, Cui-E Xue, Mario Di Gioacchino, Qiao Niu*. Effects of benzo[a]pyrene on autonomic nervous system of coke oven workers. Journal of Occupational Health. 2008, 50(4): 308-316. (4区,IF=1.848)

18.孙敏, 李欢, 周小玲, 王旭红, 聂会祥, 李新,张红梅*.焦炉工人尿酚水平与血生化指标的关系. 中华劳动卫生职业病杂志, 2020, 38(6): 440-443.

19.李欢, 孙敏, 曹晶晶, 刘爱香,张红梅*.苯并[a]芘致小鼠认知功能障碍及脑细胞中miRNA的表达. 环境与健康杂志, 2019, 36(4): 320-323.