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王明秀

王明秀

博士，讲师，E-mail：wangmingxiu0818@163.com

教育经历：

2020.09-2023.07 中国科学院大学 化学科学学院 分析化学 理学博士

2012.09-2015.07 中科院武汉病毒研究所 微生物学 理学硕士

2008.09-2012.07 中北大学 生物工程 工学学士

工作经历：

2019.01-至今，山西医科大学 公共卫生学院 卫检教研室 讲师

2015.09-2018.12，山西医科大学 公共卫生学院 卫检教研室 助教

教学情况：

1.主要承担本科生《病毒学检验》、《卫生微生物学》、《细菌学检验》、《卫生检疫学》等课程；

2.主持山西省教育改革课题1项、山西医科大学教改课题1项，发表教改文章1篇；

3.指导本科生获批2024年省级大学生创新创业训练项目《过氧化氢荧光探针的设计合成及生物成像应用》。

研究方向：

荧光探针的设计、合成及检测研究

代表性科研项目：

1. 2025.06-2026.06，煤炭环境致病与防治教育部重点实验室开放课题（MEKLCEPP/SXMU-202507），5万元，参与，在研；

2. 2019.09-2022.12，山西省应用基础研究（201901D211328）：基于纳米金属有机框架材料的活细胞水平宫颈癌标志物检测新方法研究，3万元，主持，已结题；

3. 2017.01-2020.12，病毒学国家重点实验室开放研究基金（2017IOV005）：H2S在HIV-1感染U937单核细胞过程中的信号作用机制，6万元，主持，已结题。

代表性论著：

1.Mingxiu Wang#, Ling Liu#, Yuqing Qin, Liangpo Liu, Linping Wang, Hong Cui, Xia Bian, Qingling Xu*. A two-photon fluorescent probe for sensitive detection and imaging of hypochlorite in depression model.Talanta, 2025, 297: 128694. (中科院分区, 1区top,IF: 6.1)

2.Mingxiu Wang, Haoran Wang, Heqian Zhao, Guixin Qin, Lixin Ma*, Qingling Xu*, Juyoung Yoon*. Development of a hydrogen peroxide fluorescent probe for the rapid discrimination of IDH1 mutant gliomas from the wild-type.Sensors & Actuators: B. Chemical, 2024, 412: 135850. (中科院分区, 1区top,IF: 8.4)

3.Mingxiu Wang, Feng Zhang, Cai-Qi Wang, Nan Yin, Yuting Wang, Guixin Qin, Qingling Xu*, Jianhua Gong*, Huizhen Liu*, Xinrui Duan*. Target-binding accelerated response for sensitive detection of basal H2O2in tumor cells and tissues via a dual-functional fluorescence probe.Analytical Chemistry, 2022, 94: 5962-5969. (中科院分区, 1区top,IF: 7.4)

4. Yunxia Wang, Ye Liu, Bo Liu, Yihua Yuan, Lixia Wei,Mingxiu Wang*, Zhe Chen*. A benzil- and BODIPY-based turn-on fluorescent probe for detection of hydrogen peroxide.Molecules, 2023, 29: 229. (中科院分区, 2区,IF: 4.6)

5. Yingxin Ma#,Mingxiu Wang#, Wei Li, Zhiping Zhang, Xiaowei Zhang, Tianwei Tan, Xian-En Zhang*, Zongqiang Cui*. Live cell imaging of single genomic loci with quantum dot-labeled TALEs.Nature Communications, 2017, 8: 15318. (中科院分区, 1区top,IF: 16.6)

6. Yingxin Ma#,Mingxiu Wang#, Wei Li, Zhiping Zhang, Xiaowei Zhang, Guoqiang Wu, Tianwei Tan, Zongqiang Cui*, Xian-En Zhang*. Live visualization of HIV-1 proviral DNA using a dual-color-labeled CRISPR system.Analytical Chemistry, 2017, 89: 12896-12901. (中科院分区, 1区top,IF: 7.4)

7.王明秀,张加玲,刘云凤,乔增杰.活细胞内基于Diels-Alder反应的量子点标记蛋白质研究.山西医科大学学报, 2017, 48: 895-899.

8. Guixin Qin, Lingli Gao, Nan Yin,Mingxiu Wang, Yuting Wang, Jiali Tang, Jianhua Gong*, Qingling Xu*. A selective mitochondria-targeted fluorescent probe for imaging cysteine in drug-induced liver injury.Talanta, 2025, 282: 127056.

9. Nan Yin, Yuting Wang, Guixin Qin,Mingxiu Wang, Jiali Tang, Xin Yao, Qingling Xu*, Juyoung Yoon*. A mitochondria-targeted fluorescent probe for revealing H2O2elevation modulated by basal HClO in HeLa and A549 cells.Sensors and Actuators: B. Chemical, 2024, 419: 136419. Sensors and Actuators: B. Chemical, 2024, 419: 136419.

10. Yuting Wang, Xiaoyu Cheng, Nan Yin,Mingxiu Wang, Guixin Qin, Jiali Tang, Yinlong Zhang* Qingling Xu*. A Hypochlorite-Activated Theranostic Prodrug for Selective Imaging of High Myeloperoxidase Expression Acute Myeloid Leukemia Cells and Drug Release.Analytical Chemistry, 2017, 89: 12896-12901. 2024, 96: 12238–12245.

11. Jiali Tang,Mingxiu Wang, Yuting Wang, Nan Yin, Guixin Qin, Xueting Yang, Huan Lu*, Bin Han, Qingling Xu,**, Xin Yao. Fluorescence turn-on detection of tannic acid using a 6, 7-dihydroxycoumarin-Fe3+complex.Sensors and Actuators: B. Chemical, 2024, 403: 135174.

12. Hong Cui#, Shuaishuai Cui#, Siyuan Zhang, Qiuju Tian, Yunfeng Liu, Ping Zhang,Mingxiu Wang, Jialing Zhang and Xiangjun Li*. Cu-MOFs/Hemin: A bionic enzyme with excellent dispersity for the determination of hydrogen peroxide released from living cells.Analyst, 2021, 146: 5951-5961.

13. Hong Cui#, Shuaishuai Cui#, Qiuju Tian, Siyuan Zhang,Mingxiu Wang, Ping Zhang, Yunfeng Liu, Jialing Zhang, Xiangjun Li*. Electrochemical sensor for detection of 1-hydroxypyrene based on a PAMAM regulated chromium-centered metal-organic framework and graphene oxide composite.ACS Omega, 2021, 6: 31184-31195.

专利：

14.国家发明专利《荧光探针及其在胶质瘤IDH突变检测中的应用》,专利号: ZL 2023 1 0543470.1,发明人:徐庆岭,王明秀.授权日期: 2026年01月27日