郭建全

郭建全

男，汉族，1985年05月出生，讲师。长期从事癌症治疗相关的医药技术研究。在挖掘癌症治疗靶点的同时，将纳米医药技术和合成生物学技术与癌症的预防和治疗有效结合，利用组蛋白仿生药物递送系统进行癌症治疗，相关成果发表于Bioactive Materials（Top一区，18.9）；同时利用微生物作为底盘细胞进行药物合成以及递送研究。截止目前主持山西省自然科学基金2项，山西省高等学校科技创新基金项目1项，山西省博士后基金1项，并作为骨干成员参与国家自然科学基金等各类基金多项。以第一或通讯作者发表SCI论文10篇。

教育经历

2011.09-2016.03哈尔滨工业大学，生物医学工程，博士

2008.09-2011.06东北农业大学，应用微生物，硕士

2004.09-2008.06潍坊学院，生物科学，学士

工作经历

2016.03-至今山西医科大学公共卫生学院，卫生检验与检疫教研室

学习经历

2018.06-2023.05，山西医科大学第一临床医学院博士后工作站，博士后

教学情况

全国高质量医学教师教学发展在线课程负责人，山西省一流精品认定课程负责人，山西医科大学思政示范课程负责人，主持山西省教育改革课题1项，山西医科大学教改课题2项，荣获第四届全国高校混合式教学设计创新大赛一等奖；全国卫生检验与检疫专业青年教师教学技能大赛二等奖和优秀教案奖；山西省教师教学创新大赛二等奖；山西医科大学《免疫学检验》课程混合式教学设计一等奖；山西医科大学教师教学创新大赛一等奖；山西医科大学优秀教师等。主要承担本科生《免疫学检验》、《卫生微生物学》、《细菌学检验》等课程。

代表性科研项目

1山西省科技厅,山西省应用基础研究，202203021211244, Msi-1在去势抵抗性前列腺癌异常糖代谢中的调控作用和分子机制研究, 2023-01至2025-12, 8万元,在研,主持。

2山西省人社厅,博士后专项,晋人社厅函[2020]1015号,联合¹⁸F-FDG PET显像探究Msi1靶向HIF-1α增强前列腺癌骨转移的机制, 2021-01至2023-06, 14万元, 结题,主持。

3山西省教育厅,山西省高等学校科技创新项目, 2019L0419, Musashai1靶向TGF-β信号通路促进去势诱导的EMT的机制研究, 2019-07至2022-06, 2万元,结题,主持。

4山西省科技厅,山西省应用基础研究，201801D221396,雄激素/AR/miR-101轴靶向Msi1负调控ADT诱导EMT的机制研究, 2018-12至2020-12, 3万元,结题,主持。

代表性论著：*代表通讯作者

(1) Bangyuan Zhou; Yali Niu; Dan Wang; Liangpo Liu; Jianquan Guo*; Geraniol alleviates liver injury induced by bisphenol A via modulating NLRP3/caspase 1 pathway and gut microbiota in mice model. Food Science and Biotechnology (2024) 33:3119–3130.（中科院分区3区，IF:3.2）

(2)Jianquan Guo，Liyang Yang. Regulation effect of the intestinal flora and intervention strategies targeting the intestinal flora in alleviation of pulmonary fibrosis development. Biosci Microbiota Food Health 2024;43(4):293-299.（中科院分区4区，IF:3.1）

(3) Liyang, Yang; Yali, Niu;Jianquan Guo*. Un-avoided polycyclic aromatic hydrocarbons exposure on human and animals: current detoxication strategies and future prospects. Int J Environ Health Res 2024 Nov 20;0(0):1-14.（中科院分区4区，IF:2.3）

(4)Jianquan, Guo; Bangyuan, Zhou; Yali, Niu; Liangpo, Liu; Liyang, Yang. Engineered probiotics introduced to improve intestinal microecology for the treatment of chronic diseases: present state and perspectives.J Diabetes Metab Disord 2023 Dec;22(2):1029-1038.（中科院分区4区，IF:1.8）

(5)Guo Jianquan; Tan Dongsheng; Lou Chenmei; Guo Shiying; Jin Xing; Qu Haijing; Jing Lijia; Li Sijin ; A tumor-penetrable drug nanococktail made from human histones for interventional nucleus-targeted chemophotothermal therapy of drug-resistant tumors, Bioactive Materials, 2022, 9: 554-565.（中科院分区1区Top，IF:18.9）

(6) Li Yang, Yang; Qiang, Gong;Jianquan, Guo*; Gui Lan, Li*. Microbes as a production host to produce natural activecompounds from mushrooms: biosynthetic pathway elucidationand metabolic engineering. Chin J Nat Med. 2021 Aug;19(8):580-590.（中科院分区2区，IF:5.2）

(7)Guo, Jianquan*; Feng, Shengwen; Cheng, Xiaoyu ; Activity evaluation of glycolytic promoters from Escherichia coli and application for mevalonate biosynthesis, Journal of Microbiological Methods, 2020, 174.（中科院分区4区，IF:2.0）

(8) Yang, Liyang; Li, Guilan; Chai, Zhi; Gong, Qiang;Guo, Jianquan* ; Synthesis of cordycepin: Current scenario and future perspectives, Fungal Genetics and Biology, 2020, 143.（中科院分区3区，IF:3.0）

(9)Guo, Jianquan; Mei, Yu; Li, Kai; Huang, Xuemei; Yang, Huanjie ; Downregulation of miR-17-92a cluster promotes autophagy induction in response to celastrol treatment in prostate cancer cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 478(2): 804-810.（中科院分区3区，IF:3.1）

(10)Guo, Jianquan; Huang, Xuemei; Wang, Hui; Yang, Huanjie ; Celastrol Induces Autophagy by Targeting AR/miR-101 in Prostate Cancer Cells., PLoS One, 2015, 10(10): e0140745-e0140745.（中科院分区3区，IF:3.1）

(11) Ben, Li; Ting, Liu; Yongmei, Shen; Jiangnan, Qin; Xiaohan, Chang; Meiqiong, Wu; Jianquan, Guo;Liangpo, Liu; Cailing, Wei; Yi, Lyu; Fengjie, Tian; Jinzhu, Yin; Tong, Wang; Wenping, Zhang; Yulan, Qiu.TFEB/LAMP2 contributes to PM(0.2)-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes.J Environ Sci (China) 2024 Nov;145(0):117-127.（中科院分区2区，IF:5.9）

(12) Liping, Liu; Tiedong, Sun; Feng, Xin; Wei, Cui; Jianquan, Guo; Jian, Hu. Nerve Growth Factor Protects Against Alcohol-Induced Neurotoxicity in PC12 Cells via PI3K/Akt/mTOR Pathway. Alcohol Alcohol 2017 Jan;52(1):12-18.（中科院分区4区，IF:2.0）

(13) Liangpo, Liu; Peixia, Yan; Jifang, Lv; Xuan, Liu; Junxia, Zhao; Jianquan, Guo; Guiying, Liu; Xia, Bian; Linying, Gao; Wei, Yan; Qiansheng, Huang; Guixia, Chen. Optimization and application of a method to determine 24 perfluorinated compounds in umbilical cord serum by using liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2022 Sep 1;1207(0):123365.（中科院分区3区，IF:3.0）

(14)Liangpo, Liu; Peixia, Yan; Xuan, Liu; Junxia, Zhao; Meiping, Tian; Qingyu, Huang; Jianbo, Yan; Zhendong, Tong; Yongli, Zhang; Jie, Zhang; Tongjie, Zhang; Jianquan, Guo; Guiying, Liu; Xia, Bian; Ben, Li; Tong, Wang; Heng, Wang; Heqing, Shen. Profiles and transplacental transfer of per- and polyfluoroalkyl substances in maternal and umbilical cord blood: A birth cohort study in Zhoushan, Zhejiang Province, China. J Hazard Mater 2024 Mar 15;466(0):133501J Hazard Mater 2024 Mar 15;466(0):133501.（中科院分区1区Top，IF:12.2）

(15) Ben, Li; Xiaohan, Chang; Xiaomin, Liang; Ting, Liu; Yongmei, Shen; Qianwen, Zhang; Xiaohui, Yang; Yi, Lyu; Liangpo, Liu; Jianquan, Guo; Meiqiong, Wu; Yi, Gao; Xiaoyan, Yan; Tong, Wang; WenPing, Zhang; Yulan, Qiu; JinPing, ZhengThe role of reactive astrocytes in neurotoxicity induced by ultrafine particulate matter. Sci Total Environ 2023 Apr 1;867(0):161416.（中科院分区1区Top，IF:8.1）